Evidence map›Paper›PMID 38616715›Full record

SynthesisDisease models & mechanisms2024

Systematic review and meta-analysis of the effect of bone marrow-derived cell therapies on hind limb perfusion.

Femke Christina Ching-Chuan van Rhijn-Brouwer, Kimberley Elaine Wever, Romy Kiffen, Jon-Ruben van Rhijn, Hendrik Gremmels, Joost Ougust Fledderus, Robin Wilhelmus Maria Vernooij, Marianne Christina Verhaar

Open access · goldAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Disease models & mechanisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Femke Christina Ching-Chuan van Rhijn-BrouwerDepartment of Nephrology and Hypertension, Regenerative Medicine Center Utrecht, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0002-7777-646X
Kimberley Elaine WeverDepartment of Anaesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-3635-3660
Romy KiffenDepartment of Anaesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Jon-Ruben van RhijnInstitute of Life Sciences and Chemistry, HU University of Applied Sciences Utrecht, 3584 CS Utrecht, The Netherlands.ORCID 0000-0002-4771-9755
Hendrik GremmelsDepartment of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0002-7818-620X
Joost Ougust FledderusDepartment of Nephrology and Hypertension, Regenerative Medicine Center Utrecht, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Robin Wilhelmus Maria VernooijDepartment of Nephrology and Hypertension, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Marianne Christina VerhaarDepartment of Nephrology and Hypertension, Regenerative Medicine Center Utrecht, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0002-3276-6428
Utrecht University · NLRadboud University Nijmegen · NLUniversity Medical Center Utrecht · NLUniversity of Applied Sciences Utrecht · NL

Funding

The Netherlands Organization for Health Research and Development 114024116Universiteit Utrecht
6 · The paper itself

Abstract

Preclinical and clinical studies on the administration of bone marrow-derived cells to restore perfusion show conflicting results. We conducted a systematic review and meta-analysis on preclinical studies to assess the efficacy of bone marrow-derived cells in the hind limb ischemia model and identify possible determinants of therapeutic efficacy. In vivo animal studies were identified using a systematic search in PubMed and EMBASE on 10 January 2022. 85 studies were included for systematic review and meta-analysis. Study characteristics and outcome data on relative perfusion were extracted. The pooled mean difference was estimated using a random effects model. Risk of bias was assessed for all included studies. We found a significant increase in perfusion in the affected limb after administration of bone marrow-derived cells compared to that in the control groups. However, there was a high heterogeneity between studies, which could not be explained. There was a high degree of incomplete reporting across studies. We therefore conclude that the current quality of preclinical research is insufficient (low certainty level as per GRADE assessment) to identify specific factors that might improve human clinical trials.

Indexed as

Bone Marrow CellsHindlimbIschemiaAnimalsBone Marrow TransplantationCell- and Tissue-Based TherapyHumansPerfusionPublication BiasCell therapyHind limb ischemiaMeta-analysisPerfusionSystematic review

Identifiers

PMID38616715
PMCPMC11139036
OpenAlexW4394817902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.