Evidence map›Paper›PMID 38616546›Full record

ArticleESC heart failure2024

Ca2+/calmodulin-dependent kinase IIδC-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak.

Matthias Dewenter, Tilmann Seitz, Julia H Steinbrecher, B Daan Westenbrink, Haiyun Ling, Stephan E Lehnart, Xander H T Wehrens, Johannes Backs, Joan Heller Brown, Lars S Maier and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Stress-Induced calcium mishandling in cardiac (Patho)physiology.Cellular and molecular life sciences : CMLS · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 3 countries.

Matthias DewenterMedical Faculty Heidelberg, Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.
Tilmann SeitzDZHK (German Centre for Cardiovascular Research), Partner Sites Heidelberg/Mannheim and Göttingen, Heidelberg/Mannheim and Göttingen, Germany.
Julia H SteinbrecherDZHK (German Centre for Cardiovascular Research), Partner Sites Heidelberg/Mannheim and Göttingen, Heidelberg/Mannheim and Göttingen, Germany.
B Daan WestenbrinkDepartment of Pharmacology, University of California San Diego, San Diego, CA, USA.
Haiyun LingDepartment of Pharmacology, University of California San Diego, San Diego, CA, USA.
Stephan E LehnartDZHK (German Centre for Cardiovascular Research), Partner Sites Heidelberg/Mannheim and Göttingen, Heidelberg/Mannheim and Göttingen, Germany.
Xander H T WehrensCardiovascular Research Institute and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Johannes BacksMedical Faculty Heidelberg, Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.
Joan Heller BrownDepartment of Pharmacology, University of California San Diego, San Diego, CA, USA.
Lars S MaierDepartment of Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg, Germany.
Stefan NeefDepartment of Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg, Germany.
University Hospital Regensburg · DEUniversity of Göttingen · DEBaylor College of Medicine · USEuropean Molecular Biology Organization · DEGerman Centre for Cardiovascular Research · DEHeidelberg University · DEUniversity of California San Diego · USUniversity of Groningen · NLUniversity of San Diego · US

Funding

Program AdministrationP01HL080101 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2006 to 2015
$23.4M
Ryanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5M
RhoA mediated survival signals in cardiomyocytesR37HL028143 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER · 2010 to 2019
$4.0M
Junctophilin-2 cleavage in ischemic heart diseaseR01HL153350 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2021 to 2024
$2.3M
Role of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1M
Cardiomyocyte CaM kinase II as a driver of cardiac inflammation and remodelingR01HL145459 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, MIYAMOTO, SHIGEKI · 2019 to 2022
$1.6M
STRUCTURE FUNCTION OF STUDIES OF PHOSPHOLIPASE A2F32HL008252 · NHLBI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI KELLEY, MICHAEL J. · 1990 to 1991
–
American Heart Association 0825268FDeutsche Forschungsgemeinschaft CRC1002Deutsche Forschungsgemeinschaft CRC1550Deutsche Forschungsgemeinschaft NE 2159/3-1Deutsche Forschungsgemeinschaft SFBTRR374Deutsche Gesellschaft für KardiologieDeutsches Zentrum für Herz-Kreislaufforschung B 15-014European Union 101080905Medical Faculty HeidelbergNetherlands Heart Foundation 2007T046Netherlands Organisation for Scientific Research 016-106-117NHLBI NIH HHS P01 HL080101NHLBI NIH HHS P01HL080101NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01-HL089598NHLBI NIH HHS R01 HL145459NHLBI NIH HHS R01HL145459NHLBI NIH HHS R01 HL153350NHLBI NIH HHS R01-HL153350NHLBI NIH HHS R01 HL160992NHLBI NIH HHS R01-HL160992NHLBI NIH HHS R37 HL028143NHLBI NIH HHS R37HL028143University of Regensburg
6 · The paper itself

Abstract

aimsHyperactivity of Ca METHODS AND

resultsWe crossbred CaMKIIδC overexpressing [transgenic (TG)] mice with RyR2-S2814A knock-in mice that are resistant to CaMKII-dependent RyR2 phosphorylation. Ca

conclusionsS2814 phosphoresistance of RyR2 prevents the CaMKII-dependent SR Ca

Indexed as

CalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Heart FailureMice, TransgenicMyocytes, CardiacRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumAnimalsCalcium SignalingChronic DiseaseDisease Models, AnimalMicePhosphorylationCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Ryanodine Receptor Calcium Release ChannelCa2+/calmodulin‐dependent kinase IIHeart failureRyanodine receptor 2SR Ca2+ leak

Identifiers

PMID38616546
PMCPMC11287324
OpenAlexW4394818571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.