ArticleBMC medicine2024
Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants.
Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Additive Burden of Low Peak Expiratory Flow and Sleep Disturbance on Incident Depressive Symptoms in Later Life: A Four-Cohort Longitudinal Study of 49,201 Participants.Healthcare (Basel, Switzerland) · 2026Article
- Combined association of genetic predisposition and healthy lifestyle with lung cancer risk: a population-based cohort study.Translational lung cancer research · 2026Article
- The cholesterol, high-density lipoprotein, and glucose index and its derived indices predict cardiometabolic multimorbidity development and progression in metabolic dysfunction-associated steatotic liver disease individuals: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Observational
- Early-life exposure to sugar rationing and long-term risk of depression and anxiety: a population-based natural experiment.Molecular psychiatry · 2026Article
- Associations between the C-reactive protein-triglyceride-glucose index and its derived indices and the incidence and progression of cardiometabolic multimorbidity in participants with metabolic dysfunction-associated steatotic liver disease: a large-scale prospective cohort study.Cardiovascular diabetology · 2026Article
- Associations between socioeconomic factors and mental symptoms highlight whole-body correlates and pathways.iScience · 2026Article
- Lung function impairment and risk of sepsis and sepsis-related mortality: a large cohort study with over 310,000 participants.Science China. Life sciences · 2026Article
- Comparative Performance of 3 Analytical Models in Identifying Associated Factors of Pulmonary Dysfunction-Depression Comorbidity: China Health and Retirement Longitudinal Study-Based Nationwide Cross-Sectional Study.JMIR medical informatics · 2026Article
- Associations between respiratory diseases and lung cancer risk: a secondary analysis of the large-scale prospective UK biobank cohort.BMJ open respiratory research · 2026Article
- The Association Between Depression and Idiopathic Pulmonary Fibrosis: A Prospective Study in the UK Biobank.Journal of epidemiology and global health · 2026Article
- Article
- A Prediction Model for 9-Year Depression Risk Among Patients With COPD in China.Depression and anxiety · 2026Article
- Correlation analysis of serum galectin-3 combined with Th1/Th2-related cytokines and severe anxiety and depression symptoms in patients with chronic obstructive pulmonary disease.Frontiers in psychiatry · 2026Article
- High Myopia as a Risk Factor for Severe Liver Disease in Individuals with Liver Dysfunction: Evidence from a Prospective Cohort.Journal of clinical medicine · 2025Article
- Decoding mechanisms and protein markers in lung-brain axis.Respiratory research · 2025Review
- Moderating role of live microbe between chronic inflammatory airway disease and depressive symptoms.Frontiers in nutrition · 2025Article
- Associations between pulmonary function and depression: evidence from the CHARLS cohort 2015-2018.Frontiers in public health · 2025Article
- Impaired pulmonary function increases the risk of gout: evidence from a large cohort study in the UK Biobank.BMC medicine · 2024Article
- Association of lymphocyte-to-C-reactive protein ratio with cerebral small vessel disease: a cross-sectional study based on dose-response analysis.Frontiers in neurology · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLung health is increasingly recognized as an essential factor in mental health. However, prospective evidence on lung function with incident depression remains to be determined. The study aimed to examine the prospective association between impaired lung function and incident depression and the underlying biological mechanisms.
methodsThis prospective cohort study comprised 280,032 non-depressed individuals with valid lung function measurements from the UK Biobank. Lung function was assessed through the forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV
resultsA total of 9514 participants (3.4%) developed depression during a median follow-up of 13.91 years. Individuals in the highest quartile had a lower risk of depression (FVC % predicted: HR = 0.880, 95% CI = 0.830-0.933; FEV
conclusionsThis study revealed that the higher risk of developing depression was associated with impaired lung function. Also, the association might be partially mediated by biomarkers including systemic inflammation, erythrocytes, and liver and renal function, though these mediation findings should be interpreted with caution due to potential temporal ambiguity.
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