ArticleBMC ophthalmology2024
Corneal endothelial cell density and associated factors among adults at a regional referral hospital in Uganda: a cross-sectional study.
Article in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 1 citations in OpenAlex.
- Central corneal endothelial morphometry in emmetropic adults aged 20-40 years examined in Valencia, Spain: a retrospective cross-sectional analysis.Surgical and radiologic anatomy : SRA · 2026Article
- Endothelial Cell Loss After Phacoemulsification in a Romanian Cohort: Early Outcomes and Associated Risk Factors.Diagnostics (Basel, Switzerland) · 2026Article
- Stability selection machine learning identifies biomechanical markers for subclinical idiopathic corneal endothelial abnormalities.Frontiers in medicine · 2026Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
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Abstract
backgroundTo assess the prevalence of low corneal endothelial cell density and correlates of corneal endothelial cell density among adults attending Mbarara University and Referral Hospital Eye Centre in Uganda.
methodsIn this hospital-based cross-sectional study, participants 18 years and older, were enrolled. We obtained informed consent, and basic demographic data. We also conducted visual acuity, a detailed slit lamp examination, intra-ocular pressure, corneal diameter, tear-film break-up time, keratometry, A-scan, and pachymetry on all participants. A confocal microscope Heidelberg HRT3 was used to examine the central cornea and to obtain the mean cell density (cells/mm
resultsWe evaluated a total of 798 eyes of 404 participants aged between 18 and 90 years (males = 187, females = 217). The average endothelial cell density was 2763.6 cells/mm
conclusionOur study established baseline normal ranges of ECD in a predominantly black African population, and found that low ECD is rare in our population. The elderly, smokers, and those with past ocular surgery are the most vulnerable. The low prevalence could be due to a lack of reference values for the black African population.
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