Evidence map›Paper›PMID 38615751›Full record

ArticleContemporary clinical trials2024

Neurocognitive and neurobehavioral mechanisms of change following psychological treatment for alcohol use disorder.

Barbara S McCrady, Eric Claus, Katie Witkiewitz, Alicia Shiver, Megan Swartz, Roberta Chávez

Open access · greenAbstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 0 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Barbara S McCradyCenter on Alcohol, Substance use, And Addictions; Department of Psychology, University of New Mexico, United States. Electronic address: bmccrady@unm.edu.
Eric ClausMind Research Network, 1101 Yale Blvd NE, Albuquerque, NM 87106, United States; The Pennsylvania State University, United States.
Katie WitkiewitzCenter on Alcohol, Substance use, And Addictions; Department of Psychology, University of New Mexico, United States.
Alicia ShiverCenter on Alcohol, Substance use, And Addictions; Department of Psychology, University of New Mexico, United States.
Megan SwartzMind Research Network, 1101 Yale Blvd NE, Albuquerque, NM 87106, United States.
Roberta ChávezCenter on Alcohol, Substance use, And Addictions; Department of Psychology, University of New Mexico, United States.
Canadian Centre on Substance Use and Addiction · CAMind Research Network · USUniversity of New Mexico · US

Funding

Neurocognitive and Neurobehavioral Mechanisms of Change following Psychological Treatment for Alcohol Use DisorderR01AA025762 · NIAAA · UNIVERSITY OF NEW MEXICO · PI CLAUS, ERIC D, MCCRADY, BARBARA S · 2018 to 2022
$2.9M
NIAAA NIH HHS R01 AA025762
6 · The paper itself

Abstract

backgroundAlthough modestly effective treatments exist for alcohol use disorder (AUD), many individuals return to heavy drinking after treatment, suggesting the need for better understanding of factors that contribute to maintaining abstinence or drinking reductions. Whereas past studies identified what treatments work for AUD, recent studies focus more on why particular treatments work, and the mechanisms by which treatment leads to change. This focus on mechanisms of behavior change (MOBC) may inform the process by which treatment leads to better outcomes, and also may lead to new treatments or modifications of existing treatments that target empirically supported mechanisms known to lead to change. There is a paucity of studies examining MOBC from a neurocognitive perspective.

methodTo address this gap in knowledge, the study described here is examining emotional reactivity, alcohol cue reactivity, and cognitive control as potential MOBC at three levels of analysis - self-report, behavior, and neural.

resultsOne hundred ten treatment-seeking individuals with an AUD are being randomized to receive 8 sessions of either Cognitive Behavioral Treatment (CBT) or Mindfulness Based Treatment (MBT) after up to 4 sessions of a platform treatment focused on enhancing motivation to change. To establish the temporal relationship between changes in drinking and changes in MOBC, patients are assessed at baseline, during and immediately after treatment, and 9- and 15-months post-baseline. Relationships between changes in drinking and changes in the proposed MOBC will be examined using advanced mixed modeling techniques.

conclusionsResults should advance AUD treatment by targeting treatments to neurocognitive MOBC.

Indexed as

AlcoholismCognitive Behavioral TherapyMindfulnessAdultCognitionCuesEmotionsFemaleHumansMaleMiddle AgedMotivationRandomized Controlled Trials as TopicAdultsAlcohol use disorderCognitive-behavior therapyMindfulness-based therapyNeuroimaging

Identifiers

PMID38615751
PMCPMC11180581
OpenAlexW4394770489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.