Evidence map›Paper›PMID 38615750›Full record

ArticleContemporary clinical trials2024

Colonoscopy Outreach for Rural Communities (CORC): A study protocol of a pragmatic randomized controlled trial of a patient navigation program to improve colonoscopy completion for colorectal cancer screening.

Gina A Keppel, Brooke Ike, Brian G Leroux, Linda K Ko, Katie P Osterhage, Jeffrey D Jacobs, Allison M Cole

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05453630 (Colonoscopy Outreach for Rural Communities Aim 2), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05453630 nacompletednot on this map

Colonoscopy Outreach for Rural Communities Aim 2

TypeinterventionalSponsorUniversity of WashingtonRan2022 to 2025Enrolled527ConditionsColorectal CancerArmsPatient Navigation, Usual Care Control
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Recruiting Rural Patients for Clinical Research: Lessons From a Colorectal Cancer Screening Trial.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2026
    Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gina A KeppelDepartment of Family Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: gakeppel@uw.edu.
Brooke IkeDepartment of Family Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Brian G LerouxDepartment of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA.
Linda K KoDepartment of Health Systems and Population Health, University of Washington School of Public Health, Seattle, WA, USA.
Katie P OsterhageDepartment of Family Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Jeffrey D JacobsDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Allison M ColeDepartment of Family Medicine, University of Washington School of Medicine, Seattle, WA, USA.
University of Washington · USTheodore Roosevelt High School · US

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Rural Community Support for ColonoscopyR01CA254515 · NCI · UNIVERSITY OF WASHINGTON · PI Allison Cole, Brooke Ike · 2021 to 2026
$3.1M
NCATS NIH HHS UL1 TR002319NCI NIH HHS R01 CA254515
6 · The paper itself

Abstract

backgroundColonoscopy is one of the primary methods of screening for colorectal cancer (CRC), a leading cause of cancer mortality in the United States. However, up to half of patients referred to colonoscopy fail to complete the procedure, and rates of adherence are lower in rural areas.

objectivesColonoscopy Outreach for Rural Communities (CORC) is a randomized controlled trial to test the effectiveness of a centralized patient navigation program provided remotely by a community-based organization to six geographically distant primary care organizations serving rural patients, to improve colonoscopy completion for CRC.

methodsCORC is a type 1 hybrid implementation-effectiveness trial. Participants aged 45-76 from six primary care organizations serving rural populations in the northwestern United States are randomized 1:1 to patient navigation or standard of care control. The patient navigation is delivered remotely by a trained lay-person from a community-based organization. The primary effectiveness outcome is completion of colonoscopy within one year of referral to colonoscopy. Secondary outcomes are colonoscopy completion within 6 and 9 months, time to completion, adequacy of patient bowel preparation, and achievement of cecal intubation. Analyses will be stratified by primary care organization. DISCUSSION: Trial results will add to our understanding about the effectiveness of patient navigation programs to improve colonoscopy for CRC in rural communities. The protocol includes pragmatic adaptations to meet the needs of rural communities and findings may inform approaches for future studies and programs.

trial registrationNational Clinical Trial Identifier: NCT05453630.

trial registrationClinicalTrials.gov. Identifier: NCT05453630. Registered July 6, 2022.

Indexed as

ColonoscopyColorectal NeoplasmsEarly Detection of CancerPatient NavigationRural PopulationAgedFemaleHumansMaleMiddle AgedPragmatic Clinical Trials as TopicPrimary Health CareColonoscopyColorectal cancer screeningPatient navigationPractice-based researchPrimary careRural health

Identifiers

PMID38615750
PMCPMC11098679
OpenAlexW4394743535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.