Evidence map›Paper›PMID 38615315›Full record

ArticleArchives of toxicology2024

Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair: findings from a large cohort of young adults.

Lydia Johnson-Ferguson, Lilly Shanahan, Michelle Loher, Laura Bechtiger, Tina M Binz, Markus Baumgartner, Denis Ribeaud, Manuel Eisner, Boris B Quednow

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lydia Johnson-FergusonJacobs Center for Productive Youth Development, University of Zurich, Andreasstrasse 15, 8050, Zurich, Switzerland. lydia.johnson-ferguson@jacobscenter.uzh.ch.ORCID 0000-0003-3717-1332
Lilly ShanahanJacobs Center for Productive Youth Development, University of Zurich, Andreasstrasse 15, 8050, Zurich, Switzerland.
Michelle LoherJacobs Center for Productive Youth Development, University of Zurich, Andreasstrasse 15, 8050, Zurich, Switzerland.
Laura BechtigerJacobs Center for Productive Youth Development, University of Zurich, Andreasstrasse 15, 8050, Zurich, Switzerland.
Tina M BinzCenter for Forensic Hair Analytics, Zurich Institute of Legal Medicine, University of Zurich, Zurich, Switzerland.
Markus BaumgartnerCenter for Forensic Hair Analytics, Zurich Institute of Legal Medicine, University of Zurich, Zurich, Switzerland.
Denis RibeaudJacobs Center for Productive Youth Development, University of Zurich, Andreasstrasse 15, 8050, Zurich, Switzerland.
Manuel EisnerInstitute of Criminology, University of Cambridge, Cambridge, UK.
Boris B QuednowJacobs Center for Productive Youth Development, University of Zurich, Andreasstrasse 15, 8050, Zurich, Switzerland.
University of Zurich · CHUnion Bank of Switzerland · CHUniversity of Cambridge · GB

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 10531C_189008Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 10FI14_170402
6 · The paper itself

Abstract

Paracetamol is one of the most commonly used over-the-counter medications. Experimental studies suggest a possible stress-suppressing effect of paracetamol in humans facing experimental stress-inducing paradigms. However, no study has investigated whether paracetamol and steroid hormones covary over longer time frames and under real-life conditions. This study addresses this gap by investigating associations between steroid hormones (cortisol, cortisone, and testosterone) and paracetamol concentrations measured in human hair, indexing a timeframe of approximately three months. The data came from a large community sample of young adults (N = 1002). Hair data were assayed using liquid chromatography-tandem mass spectrometry. Multiple regression models tested associations between paracetamol and  steroid hormones, while adjusting for a wide range of potential confounders, such as sex, stressful live events, psychoactive substance use, hair colour, and body mass index. Almost one in four young adults from the community had detectable paracetamol in their hair (23%). Higher paracetamol hair concentrations were robustly associated with more cortisol (β = 0.13, η

Indexed as

AcetaminophenHairHydrocortisoneAdolescentAdultAnalgesics, Non-NarcoticChromatography, LiquidCohort StudiesCortisoneFemaleGlucocorticoidsHumansMaleTandem Mass SpectrometryTestosteroneYoung AdultAcetaminophenAnalgesics, Non-NarcoticCortisoneGlucocorticoidsHydrocortisoneTestosteroneCortisolCortisoneHairParacetamolTestosterone

Identifiers

PMID38615315
PMCPMC11168975
OpenAlexW4394794273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.