Evidence map›Paper›PMID 38615126›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024

In vivo translocator protein in females with autism spectrum disorder: a pilot study.

Chieh-En Jane Tseng, Camila Canales, Rachel E Marcus, Anjali J Parmar, Baileigh G Hightower, Jennifer E Mullett, Meena M Makary, Alison U Tassone, Hannah K Saro, Paige Hickey Townsend and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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  8. Upregulated inwardly rectifying KJournal of biomedical research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 2 countries.

Chieh-En Jane TsengAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID http://orcid.org/0000-0003-0592-335X
Camila CanalesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Rachel E MarcusAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Anjali J ParmarAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Baileigh G HightowerAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Jennifer E MullettLurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA.
Meena M MakaryAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Alison U TassoneLurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA.
Hannah K SaroLurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA.
Paige Hickey TownsendAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Kirstin BirtwellHarvard Medical School, Boston, MA, USA.
Lisa NowinskiHarvard Medical School, Boston, MA, USA.
Robyn P ThomHarvard Medical School, Boston, MA, USA.
Michelle L PalumboHarvard Medical School, Boston, MA, USA.
Christopher KearyHarvard Medical School, Boston, MA, USA.
Ciprian CatanaAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID http://orcid.org/0000-0002-3249-5971
Christopher J McDougleHarvard Medical School, Boston, MA, USA.
Jacob M HookerAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID http://orcid.org/0000-0002-9394-7708
Nicole R ZürcherAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA. nzurcherwimmer@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-0271-6304
Harvard University · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex-based differences in the prevalence of autism spectrum disorder (ASD) are well-documented, with a male-to-female ratio of approximately 4:1. The clinical presentation of the core symptoms of ASD can also vary between sexes. Previously, positron emission tomography (PET) studies have identified alterations in the in vivo levels of translocator protein (TSPO)-a mitochondrial protein-in primarily or only male adults with ASD, with our group reporting lower TSPO relative to whole brain mean in males with ASD. However, whether in vivo TSPO levels are altered in females with ASD, specifically, is unknown. This is the first pilot study to measure in vivo TSPO in the brain in adult females with ASD using [

Indexed as

Autism Spectrum DisorderBrainPositron-Emission TomographyReceptors, GABAAdolescentAdultFemaleHumansMalePilot ProjectsSex CharacteristicsYoung AdultReceptors, GABATSPO protein, human

Identifiers

PMID38615126
PMCPMC11109261
OpenAlexW4394783511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.