Evidence map›Paper›PMID 38615104›Full record

ArticleNPJ digital medicine2024

Deep learning evaluation of echocardiograms to identify occult atrial fibrillation.

Neal Yuan, Nathan R Stein, Grant Duffy, Roopinder K Sandhu, Sumeet S Chugh, Peng-Sheng Chen, Carine Rosenberg, Christine M Albert, Susan Cheng, Robert J Siegel and 1 more

Open access · goldAbstract read
In one paragraph

Article in NPJ digital medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Time's imprint on the left atrium: aging and atrial myopathy.The journal of cardiovascular aging · 2025
    Article
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  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Neal YuanSchool of Medicine, University of California, San Francisco, CA; Division of Cardiology, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA. Neal.Yuan@ucsf.edu.ORCID http://orcid.org/0000-0001-5782-7437
Nathan R SteinCedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
Grant DuffyCedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
Roopinder K SandhuCedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
Sumeet S ChughCedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
Peng-Sheng ChenCedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
Carine RosenbergCedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
Christine M AlbertCedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
Susan ChengCedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4977-036X
Robert J SiegelCedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
David OuyangCedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3813-7518
Cedars-Sinai Smidt Heart Institute · USSan Francisco VA Medical Center · US

Funding

SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular ArrhythmogenesisR01HL139829 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PENG-SHENG CHEN, ZHILIN QU · 2018 to 2026
$4.5M
Deep Learning Based Phenotyping and Outcomes Prediction for Valvular Heart DiseaseR01HL173526 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI David Ouyang · 2024 to 2026
$2.5M
Using electrical nerve stimulation to control atrial fibrillation.OT2OD028190 · OD · INDIANA UNIVERSITY INDIANAPOLIS · PI CHEN, PENG-SHENG · 2019 to 2021
$2.3M
Deep Learning Assessment of the Right Ventricle: Function, Etiology, and PrognosisR00HL157421 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI OUYANG, DAVID · 2023 to 2025
$747k
Deep Learning Assessment of the Right Ventricle: Function, Etiology, and PrognosisK99HL157421 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI OUYANG, DAVID · 2021 to 2022
$313k
American Heart Association-American Stroke Association 23IPA1052289NHLBI NIH HHS K99 HL157421NHLBI NIH HHS R00 HL157421NHLBI NIH HHS R01 HL139829NHLBI NIH HHS R01 HL173526NIH HHS OT2 OD028190
6 · The paper itself

Abstract

Atrial fibrillation (AF) often escapes detection, given its frequent paroxysmal and asymptomatic presentation. Deep learning of transthoracic echocardiograms (TTEs), which have structural information, could help identify occult AF. We created a two-stage deep learning algorithm using a video-based convolutional neural network model that (1) distinguished whether TTEs were in sinus rhythm or AF and then (2) predicted which of the TTEs in sinus rhythm were in patients who had experienced AF within 90 days. Our model, trained on 111,319 TTE videos, distinguished TTEs in AF from those in sinus rhythm with high accuracy in a held-out test cohort (AUC 0.96 (0.95-0.96), AUPRC 0.91 (0.90-0.92)). Among TTEs in sinus rhythm, the model predicted the presence of concurrent paroxysmal AF (AUC 0.74 (0.71-0.77), AUPRC 0.19 (0.16-0.23)). Model discrimination remained similar in an external cohort of 10,203 TTEs (AUC of 0.69 (0.67-0.70), AUPRC 0.34 (0.31-0.36)). Performance held across patients who were women (AUC 0.76 (0.72-0.81)), older than 65 years (0.73 (0.69-0.76)), or had a CHA

Identifiers

PMID38615104
PMCPMC11016113
OpenAlexW4394783430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.