ArticlePediatric research2024
Biventricular function in preterm infants with patent ductus arteriosus ligation: A three-dimensional echocardiographic study.
Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Left ventricular rotational mechanics mature rapidly in extreme preterm infants - but do they matter for the brain?Pediatric research · 2026Article
- Cardiac adaptations to patent ductus arteriosus ligation in preterm infants: a speckle-tracking study.Pediatric research · 2026Article
- Perioperative biventricular function in congenital diaphragmatic hernia: a three-dimensional echocardiographic study.Pediatric research · 2026Article
- Cardiac function in 6-year-old children born extremely preterm and associations to prolonged patent ductus arteriosus shunting.Scientific reports · 2026Article
- Generation of PLASE score for patent ductus arteriosus using the PLASE study database.Pediatric research · 2025Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe detailed hemodynamics after patent ductus arteriosus (PDA) ligation in preterm infants remain unknown. We aimed to clarify the effect of surgical ligation on left ventricular (LV) and right ventricular (RV) volume and function.
methodsEchocardiography was performed in 41 preterm infants (median gestational age: 25 weeks) before and after PDA ligation. Global longitudinal strain was determined using three-dimensional speckle-tracking echocardiography. These values were compared with those in 36 preterm infants without PDA (non-PDA).
resultsPreoperatively, the PDA group had greater end-diastolic volume (EDV) and cardiac output (CO) in both ventricles, a higher LV ejection fraction (LVEF) (53% vs 44%) and LV global longitudinal strain, and a lower RVEF (47% vs 52%) than the non-PDA group. At 4-8 h postoperatively, the two groups had a similar LVEDV and RVEDV. However, the PDA group had a lower EF and CO in both ventricles than the non-PDA group. At 24-48 h postoperatively, the RVEF was increased, but the LVEF remained decreased, and LVCO was increased.
conclusionsPDA induces biventricular loading and functional abnormalities in preterm infants, and they dramatically change after surgery. Three-dimensional echocardiography may be beneficial to understand the status of both ventricles. IMPACT: Preterm infants are at high risk of hemodynamic compromise following a sudden change in loading conditions after PDA ligation. Three-dimensional echocardiography enables quantitative and serial evaluation of ventricular function and volume in preterm infants with PDA. PDA induces biventricular loading and functional abnormalities in preterm infants, and they dramatically change after surgery.
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