ArticleNature communications2024
A plant NLR receptor employs ABA central regulator PP2C-SnRK2 to activate antiviral immunity.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- From activation to desensitization: How ABA balances plant growth and abiotic stress response?Plant communications · 2026Review
- An LRR-truncated NLR natural variant confers dual resistance to drought and blast in rice.Nature communications · 2026Article
- A transcription factor TOE3 simultaneously promotes growth and antiviral immunity by disrupting ABA core module in tobacco.Science advances · 2026Article
- From recognition to proteolytic control: NLRs and metacaspases in plant antiviral immunity.Journal of integrative plant biology · 2026Review
- The TaSDIR1-4A-TaASR4-3D module regulates ABA-related drought responses in wheat seedlings.The New phytologist · 2026Article
- GhPsbO breaks the growth-immunity tradeoff by simultaneously promoting growth and defense in cotton.The Plant cell · 2026Article
- AhBWR15, A Novel RLK Gene, Confers Resistance to Ralstonia solanacearum in Peanut.Plant biotechnology journal · 2026Article
- Copper-Regulated Modulation of the MdbZIP11-MdHAT5 Transcriptional Module Enhances ABA-Mediated Immunity in Apple.Molecular plant pathology · 2026Article
- Genome-Wide Analysis of AGPase IdentifiesInternational journal of molecular sciences · 2026Article
- Biotic Stress Resistance in Sweet Potato: Mechanisms, Perspectives, and Sustainable Production Strategies.Plants (Basel, Switzerland) · 2026Review
- Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase-Separated Co-Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase.Plant biotechnology journal · 2026Article
- Single-Cell Transcriptomics Reveals FLS2-Dependent Hypoxia Signaling and ERF13-Mediated Transcription During flg22-Triggered Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Join the Green and Sustainable Team: Magnesium Oxide Nanoparticles Boost Broad-Spectrum Viral Resistance in Solanaceae Plants.Plant biotechnology journal · 2026Article
- Physiological and Molecular Mechanisms of Nitrogen Regulation on Grain Quality in Cereal Crops at Later Stages.International journal of molecular sciences · 2026Review
- Abscisic acid at the crossroad of abiotic stress responses and plant-microbe interactions.PLoS pathogens · 2026Article
- Wheat Plasma Membrane Receptors: Orchestrating Immunity and Bridging to Crop Improvement.Current issues in molecular biology · 2025Review
- Protein Phosphatase OsPP2C55 Negatively Regulates Abscisic Acid Biosynthesis and Saline-Alkaline Tolerance in Rice.Plants (Basel, Switzerland) · 2025Article
- Post-Translational Modifications of TOE3 Regulate Antiviral Defense in Tobacco.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Phytohormone Signaling Pathway and Immunity Responses to BYDV Infection in Resistant and Susceptible Oat Cultivars.Plants (Basel, Switzerland) · 2025Article
- Orchestration of plant PRR- and NLR-mediated immunity: Protein kinases and beyond.Molecular cell · 2025Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defence against pathogens relies on intracellular nucleotide-binding, leucine-rich repeat immune receptors (NLRs) in plants. Hormone signaling including abscisic acid (ABA) pathways are activated by NLRs and play pivotal roles in defence against different pathogens. However, little is known about how hormone signaling pathways are activated by plant immune receptors. Here, we report that a plant NLR Sw-5b mimics the behavior of the ABA receptor and directly employs the ABA central regulator PP2C-SnRK2 complex to activate an ABA-dependent defence against viral pathogens. PP2C4 interacts with and constitutively inhibits SnRK2.3/2.4. Behaving in a similar manner as the ABA receptor, pathogen effector ligand recognition triggers the conformational change of Sw-5b NLR that enables binding to PP2C4 via the NB domain. This receptor-PP2C4 binding interferes with the interaction between PP2C4 and SnRK2.3/2.4, thereby releasing SnRK2.3/2.4 from PP2C4 inhibition to activate an ABA-specific antiviral immunity. These findings provide important insights into the activation of hormone signaling pathways by plant immune receptors.
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