Evidence map›Paper›PMID 38614630›Full record

Trial reportThe Lancet. Global health2024

Cooking with liquefied petroleum gas or biomass and fetal growth outcomes: a multi-country randomised controlled trial.

William Checkley, Lisa M Thompson, Shakir Hossen, Laura Nicolaou, Kendra N Williams, Stella M Hartinger, Marilu Chiang, Kalpana Balakrishnan, Sarada S Garg, Gurusamy Thangavel and 26 more

Erratum issued Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Lancet. Global health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02944682 (Household Air Pollution and Health), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02944682 nacompletednot on this map

Household Air Pollution and Health: A Multi-country LPG Intervention Trial

TypeinterventionalSponsorEmory UniversityRan2017 to 2025Enrolled3,640ConditionsInfant, Low Birth WeightArmsLiquefied petroleum gas (LPG) cookstove
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 14 institutions in 5 countries.

William CheckleyDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address: wcheckl1@jhmi.edu.
Lisa M ThompsonNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
Shakir HossenDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Laura NicolaouDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Kendra N WilliamsDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Stella M HartingerLatin American Center of Excellence on Climate Change and Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
Marilu ChiangBiomedical Research Unit, Asociación Benéfica PRISMA, Lima, Perú.
Kalpana BalakrishnanICMR Center for Advanced Research on Air Quality, Climate and Health, Department of Environmental Health Engineering, Sri Ramachandra Institute for Higher Education and Research, Chennai, India.
Sarada S GargICMR Center for Advanced Research on Air Quality, Climate and Health, Department of Environmental Health Engineering, Sri Ramachandra Institute for Higher Education and Research, Chennai, India.
Gurusamy ThangavelICMR Center for Advanced Research on Air Quality, Climate and Health, Department of Environmental Health Engineering, Sri Ramachandra Institute for Higher Education and Research, Chennai, India.
Vigneswari AravindalochananICMR Center for Advanced Research on Air Quality, Climate and Health, Department of Environmental Health Engineering, Sri Ramachandra Institute for Higher Education and Research, Chennai, India.
Ghislaine RosaFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Alexie MukeshimanaEagle Research Center Limited, Kigali, Rwanda.
Florien NdagijimanaEagle Research Center Limited, Kigali, Rwanda.
John P McCrackenEpidemiology and Biostatistics Department, University of Georgia, Athens, GA, USA; Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
Anaité Diaz-ArtigaCenter for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
Sheela S SinharoyHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Lance WallerDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
Jiantong WangDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
Shirin JabbarzadehDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
Yunyun ChenDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
Kyle SteenlandGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Miles A KirbyDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Usha RamakrishnanHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Michael JohnsonBerkeley Air Monitoring Group, Berkeley, CA, USA.
Ajay PillarisettiDivision of Environmental Health Sciences, University of California at Berkeley, Berkeley, CA, USA.
Eric D McCollumCenter for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Global Program in Pediatric Respiratory Sciences, Eudowood Division of Pediatric Respiratory Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Eudowood Division of Pediatric Respiratory Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Rachel CraikNuffield Department of Women's & Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Eric O OhumaCentre for Maternal, Adolescent, Reproductive & Child Health, London School of Hygiene & Tropical Medicine, London, UK.
Victor G Dávila-RománCardiovascular Imaging and Clinical Research Core Laboratory, Department of Medicine, Washington University in St Louis, St Louis, MO, USA.
Lisa de las FuentesCardiovascular Imaging and Clinical Research Core Laboratory, Department of Medicine, Washington University in St Louis, St Louis, MO, USA.
Suzanne M SimkovichCenter for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Division of Healthcare Delivery Research, MedStar Health Research Institute, Hyattsville, MD, USA; Division of Pulmonary and Critical Care Medicine, Georgetown University, Washington, DC, USA.
Jennifer L PeelDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Thomas F ClasenGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Aris T PapageorghiouNuffield Department of Women's & Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address: aris.papageorghiou@wrh.ox.ac.uk.
Household Air Pollution Intervention Network (HAPIN) Investigators
Emory University · USSri Ramachandra Institute of Higher Education and Research · INWashington University in St. Louis · USJohns Hopkins Medicine · USJohns Hopkins University · USUniversity of Oxford · GBLondon School of Hygiene & Tropical Medicine · GBUniversidad del Valle de Guatemala · GTBerkeley Air Monitoring Group (United States) · USColorado State University · USHarvard Global Health Institute · USProteogenomics Research Institute for Systems Medicine · USUniversidad Peruana Cayetano Heredia · PEUniversity of California, Berkeley · US

Funding

Household Air Pollution and Health: A Multi-Country LPG Intervention TrialUM1HL134590 · NHLBI · EMORY UNIVERSITY · PI CHECKLEY, WILLIAM, CLASEN, THOMAS F · 2016 to 2021
$31.1M
NHLBI NIH HHS UM1 HL134590
6 · The paper itself

Abstract

backgroundHousehold air pollution might lead to fetal growth restriction during pregnancy. We aimed to investigate whether a liquefied petroleum gas (LPG) intervention to reduce personal exposures to household air pollution during pregnancy would alter fetal growth.

methodsThe Household Air Pollution Intervention Network (HAPIN) trial was an open-label randomised controlled trial conducted in ten resource-limited settings across Guatemala, India, Peru, and Rwanda. Pregnant women aged 18-34 years (9-19 weeks of gestation) were randomly assigned in a 1:1 ratio to receive an LPG stove, continuous fuel delivery, and behavioural messaging or to continue usual cooking with biomass for 18 months. We conducted ultrasound assessments at baseline, 24-28 weeks of gestation (the first pregnancy visit), and 32-36 weeks of gestation (the second pregnancy visit), to measure fetal size; we monitored 24 h personal exposures to household air pollutants during these visits; and we weighed children at birth. We conducted intention-to-treat analyses to estimate differences in fetal size between the intervention and control group, and exposure-response analyses to identify associations between household air pollutants and fetal size. This trial is registered with ClinicalTrials.gov (NCT02944682).

findingsBetween May 7, 2018, and Feb 29, 2020, we randomly assigned 3200 pregnant women (1593 to the intervention group and 1607 to the control group). The mean gestational age was 14·5 (SD 3·0) weeks and mean maternal age was 25·6 (4·5) years. We obtained ultrasound assessments in 3147 (98·3%) women at baseline, 3052 (95·4%) women at the first pregnancy visit, and 2962 (92·6%) at the second pregnancy visit, through to Aug 25, 2020. Intervention adherence was high (the median proportion of days with biomass stove use was 0·0%, IQR 0·0-1·6) and pregnant women in the intervention group had lower mean exposures to particulate matter with a diameter less than 2·5 μm (PM

interpretationAlthough an LPG cooking intervention successfully reduced personal exposure to air pollution during pregnancy, it did not affect fetal size. Our findings do not support the use of unvented liquefied petroleum gas stoves as a strategy to increase fetal growth in settings were biomass fuels are used predominantly for cooking.

fundingUS National Institutes of Health and Bill & Melinda Gates Foundation. TRANSLATIONS: For the Kinyarwanda, Spanish and Tamil translations of the abstract see Supplementary Materials section.

Indexed as

Air PollutantsFetal DevelopmentAdolescentAdultBiomassCookingFemaleHumansIndiaInfant, NewbornMalePregnancyUnited StatesYoung AdultAir Pollutants

Identifiers

PMID38614630
PMCPMC11027158
OpenAlexW4394734009

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.