Evidence map›Paper›PMID 38614285›Full record

ArticleDevelopmental biology2024

A new atlas to study embryonic cell types in Xenopus.

Kseniya Petrova, Maksym Tretiakov, Aleksandr Kotov, Anne H Monsoro-Burq, Leonid Peshkin

Abstract read
In one paragraph

Article in Developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Xenbase: A Guide to the Xenopus Genetics and Genomics Knowledgebase.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Article
  4. Open carry.Fly · 2025
    Article
  5. Putative muscle stem cells promoteProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kseniya PetrovaSystems Biology, Harvard Medical School, Boston, MA, 02115, USA.
Maksym TretiakovTechnical University of Munich, Germany.
Aleksandr KotovUniversité Paris Saclay, Faculté des Sciences d'Orsay, CNRS UMR 3347, INSERM, U1021, Orsay, France; Institut Curie, PSL Research University, CNRS UMR 3347, INSERM U1021, F-91405, Orsay, France.
Anne H Monsoro-BurqUniversité Paris Saclay, Faculté des Sciences d'Orsay, CNRS UMR 3347, INSERM, U1021, Orsay, France; Institut Curie, PSL Research University, CNRS UMR 3347, INSERM U1021, F-91405, Orsay, France; Institut Universitaire de France, F-75005, Paris, France.
Leonid PeshkinSystems Biology, Harvard Medical School, Boston, MA, 02115, USA; Marine Biological Laboratory, Woods Hole, MA, 02543, USA. Electronic address: pesha@hms.harvard.edu.

Funding

XenCAT: Xenopus Single Cell AtlasR24OD031956 · OD · HARVARD MEDICAL SCHOOL · PI PESHKIN, LEON · 2022 to 2025
$3.5M
NIH HHS R24 OD031956
6 · The paper itself

Abstract

This paper introduces a single-cell atlas for pivotal developmental stages in Xenopus, encompassing gastrulation, neurulation, and early tailbud. Notably surpassing its predecessors, the new atlas enhances gene mapping, read counts, and gene/cell type nomenclature. Leveraging the latest Xenopus tropicalis genome version, alongside advanced alignment pipelines and machine learning for cell type assignment, this release maintains consistency with previous cell type annotations while rectifying nomenclature issues. Employing an unbiased approach for cell type assignment proves especially apt for embryonic contexts, given the considerable number of non-terminally differentiated cell types. An alternative cell type attribution here adopts a fuzzy, non-deterministic stance, capturing the transient nature of early embryo progenitor cells by presenting an ensemble of types in superposition. The value of the new resource is emphasized through numerous examples, with a focus on previously unexplored germ cell populations where we uncover novel transcription onset features. Offering interactive exploration via a user-friendly web portal and facilitating complete data downloads, this atlas serves as a comprehensive and accessible reference.

Indexed as

XenopusAnimalsEmbryo, NonmammalianGastrulationGene Expression Regulation, DevelopmentalNeurulationSingle-Cell Analysis

Identifiers

PMID38614285
PMCPMC11315121

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.