ArticleNeuron2024
Microglial P2Y
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Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56citing papers in PubMed
17.1field-weighted citation impact, top 1% of its field
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Who cites it
56 citing papers in PubMed, 70 citations in OpenAlex.
- Calcium signaling in microglial immune functions: current understanding and implications for disease.Current opinion in immunology · 2026Review
- ApoE impairs microglial efferocytosis by targeting Gas6/MerTK in a mouse model of acute seizure.Acta pharmacologica Sinica · 2026Article
- Purinergic signaling in osteoarthritis: Mechanistic insights into pathogenesis and therapeutic targeting.Genes & diseases · 2026Review
- β-hydroxybutyrate regulates microglia M1/M2 polarization and phagocytosis through the JAK1/STAT1 pathway to reduce neuroinflammation and exert anti-epileptic effects.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Auditory Stimulation of Slow-Wave Sleep Promotes Recovery after Brain Injury in an Animal Model.Annals of neurology · 2026Article
- Astrocyte-to-microglia purinergic signaling mediates synaptic shielding and promotes neuronal activity.bioRxiv : the preprint server for biology · 2026Article
- Human umbilical cord blood mononuclear cells ameliorate vascular dementia by modulating microglial myelin debris handling and white matter injury.Journal of neuroinflammation · 2026Article
- Microglial SWELL1 deficiency drives male-specific seizure vulnerability but paradoxical neuroprotection through impaired phagocytosis.JCI insight · 2026Article
- P2RY6Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Ondansetron reduces seizures and improves cognitive impairment in a rat model of temporal lobe epilepsy.IBRO neuroscience reports · 2026Article
- P2Y6 receptor in the superior cervical ganglion: a key mediator of post-myocardial ischemic sympathetic hyperexcitability via NF-κB mediated neuroinflammation.Purinergic signalling · 2026Article
- Uncovering the Key Circuit FOSL2/FOS/EGR3/EGR1, Contributing to the Hyperexcitability of Excitatory Neurons in the Epileptic Temporal Cortex and Hippocampus.International journal of molecular sciences · 2026Article
- Dual-targeting nanoparticles enhance microglial P2Y12R expression to promote neuronal mitophagy for repairing spinal cord injury.Cell death & disease · 2026Article
- Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis optica model induced by subarachnoid AQP4-IgG.The Journal of clinical investigation · 2026Article
- Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carryingScience advances · 2026Article
- Pyrimidinergic calcium signaling links tubular metabolism to fibrosis in kidney disease.Nature communications · 2026Article
- Microglial reactivity and neuroinflammation-driven changes in motivational behaviors are regulated by Orai1 calcium channels.Science signaling · 2026Article
- 4-Phenylbutyrate Induces Functional Elongation of the Microglial Process Through Activation of Akt.Neurochemical research · 2026Article
Corrections and comments
- Update ofMicroglial P2Y2023
Authors and funding
18 authors at 3 institutions in 2 countries.
Anthony D UmpierreDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: umpierre.anthony@mayo.edu.
Bohan LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Katayoun AyasoufiDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Whitney L SimonGraduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Shunyi ZhaoDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Manling XieDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Grace ThyenDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Benjamin HurCenter for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA.
Jiaying ZhengDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Yue LiangDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Dale B BoscoDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Mark A MaynesGraduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Zhaofa WuState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Xinzhu YuDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Jaeyun SungCenter for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA.
Aaron J JohnsonDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China. Electronic address: yulongli@pku.edu.cn.
Long-Jun WuDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA; Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address: longjun.wu@uth.tmc.edu.
Mayo Clinic · USPeking University · CNUniversity of Illinois Urbana-Champaign · US
Funding
CD8 T cell mediated disruption of Blood Brain Barrier Tight JunctionsR01NS103212 · NINDS · MAYO CLINIC ROCHESTER · PI Aaron J Johnson · 2017 to 2026
$4.6MThe Role of Microglia in EpilepsyR01NS088627 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WU, LONG-JUN · 2014 to 2023
$3.6MHow microglia sense and regulate neuronal activity in the adult brainR35NS132326 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Long-Jun Wu · 2023 to 2026
$3.2MDefining MHC class I restricted antigen presentation to CD8 T cells in experimental AD and Tauopathy - SupplementRF1NS122174 · NINDS · MAYO CLINIC ROCHESTER · PI JOHNSON, AARON J · 2021 to 2023
$2.0MMicroglial regulation of neuronal activity in TDP-43 neurodegenerationRF1AG082314 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WU, LONG-JUN · 2023 to 2023
$1.9MDefining MHC class I restricted antigen presentation to CD8 T cells in experimental AD and TauopathyR01NS122174 · NINDS · MAYO CLINIC ROCHESTER · PI JOHNSON, AARON J · 2024 to 2025
$1.2MMicroglial regulation of neuronal activity in TDP-43 neurodegenerationR01AG082314 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Long-Jun Wu · 2026 to 2026
$712kMicroglial P2Y6 receptor calcium signaling as a core regulator of epileptogenesisK99NS126417 · NINDS · MAYO CLINIC ROCHESTER · PI UMPIERRE, ANTHONY DAVID · 2022 to 2023
$236kNIA NIH HHS R01 AG082314NIA NIH HHS RF1 AG082314NINDS NIH HHS K99 NS126417NINDS NIH HHS R01 NS088627NINDS NIH HHS R01 NS103212NINDS NIH HHS R01 NS122174NINDS NIH HHS R35 NS132326NINDS NIH HHS RF1 NS122174
Abstract
Microglial calcium signaling is rare in a baseline state but strongly engaged during early epilepsy development. The mechanism(s) governing microglial calcium signaling are not known. By developing an in vivo uridine diphosphate (UDP) fluorescent sensor, GRAB
Indexed as
Calcium SignalingEpilepsyMice, KnockoutMicrogliaPhagocytosisReceptors, Purinergic P2AnimalsHippocampusLysosomesMaleMiceMice, Inbred C57BLNeuroimmunomodulationNeuronsUridine Diphosphatepurinoceptor P2Y6Receptors, Purinergic P2Uridine Diphosphatecalcium signalingCalExGRAB sensorinflammationmicrogliaP2Y6phagocytosispurineseizuresUDP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.