Evidence map›Paper›PMID 38614079›Full record

ArticleCurrent biology : CB2024

The tardigrade Hypsibius exemplaris dramatically upregulates DNA repair pathway genes in response to ionizing radiation.

Courtney M Clark-Hachtel, Jonathan D Hibshman, Tristan De Buysscher, Evan R Stair, Leslie M Hicks, Bob Goldstein

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
24.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Courtney M Clark-HachtelBiology Department, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Biology Department, The University of North Carolina at Asheville, Asheville, NC 28804, USA. Electronic address: clarkcm6@email.unc.edu.
Jonathan D HibshmanBiology Department, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Tristan De BuysscherBiology Department, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Bioinformatics & Analytics Research Collaborative, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Evan R StairDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Leslie M HicksDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Bob GoldsteinBiology Department, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · US

Funding

Identification and analysis of novel tardigrade stress response mechanismsF32GM131577 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HIBSHMAN, JONATHAN · 2019 to 2022
$216k
NIGMS NIH HHS F32 GM131577
6 · The paper itself

Abstract

Tardigrades can survive remarkable doses of ionizing radiation, up to about 1,000 times the lethal dose for humans. How they do so is incompletely understood. We found that the tardigrade Hypsibius exemplaris suffers DNA damage upon gamma irradiation, but the damage is repaired. We show that this species has a specific and robust response to ionizing radiation: irradiation induces a rapid upregulation of many DNA repair genes. This upregulation is unexpectedly extreme-making some DNA repair transcripts among the most abundant transcripts in the animal. By expressing tardigrade genes in bacteria, we validate that increased expression of some repair genes can suffice to increase radiation tolerance. We show that at least one such gene is important in vivo for tardigrade radiation tolerance. We hypothesize that the tardigrades' ability to sense ionizing radiation and massively upregulate specific DNA repair pathway genes may represent an evolved solution for maintaining DNA integrity.

Indexed as

DNA RepairGamma RaysRadiation, IonizingTardigradaUp-RegulationAnimalsDNA DamageRadiation ToleranceDNA repairgenome stabilityradiation tolerancetardigrades

Identifiers

PMID38614079
PMCPMC11078613
OpenAlexW4394749595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.