Evidence map›Paper›PMID 38613803›Full record

ArticleAging2024

lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1.

Gang Du, Zhaochen Jiang, Tong Xia, Mingkun Liu, Zeyang Liu, Huaxin Zhou, Hao Zhang, Xiangyu Zhai, Bin Jin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gang DuOrgan Transplant Department, Qilu Hospital of Shangdong University, Jinan 250012, China.
Zhaochen JiangOrgan Transplant Department, Qilu Hospital of Shangdong University, Jinan 250012, China.
Tong XiaOrgan Transplant Department, Qilu Hospital of Shangdong University, Jinan 250012, China.
Mingkun LiuOrgan Transplant Department, Qilu Hospital of Shangdong University, Jinan 250012, China.
Zeyang LiuOrgan Transplant Department, Qilu Hospital of Shangdong University, Jinan 250012, China.
Huaxin ZhouDepartment of Hepatobiliary Surgery, The Second Hospital of Shangdong University, Jinan 250033, China.
Hao ZhangOrgan Transplant Department, Qilu Hospital of Shangdong University, Jinan 250012, China.
Xiangyu ZhaiDepartment of Hepatobiliary Surgery, The Second Hospital of Shangdong University, Jinan 250033, China.
Bin JinOrgan Transplant Department, Qilu Hospital of Shangdong University, Jinan 250012, China.
Qilu Hospital of Shandong University · CNSecond Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study aims to examine the involvement of lincRNA00907 in the advancement of non-alcoholic steatohepatitis (NASH).

methodsThe examination was conducted to assess the expression of linc00907 in liver tissues from NASH patients and healthy individuals. High-fat diets induced NASH in mouse models, while palmitic acid/oleic acid treatment was used to create

resultsLinc00907 was found to be significantly upregulated in both NASH patients and NASH mouse models. Overexpression of linc00907 led to an increase in intracellular lipid accumulation, while knockdown of linc00907 resulted in decreased lipid content. It was found that miRNA-942-5p binds with linc00907, and their interaction was confirmed in dual-luciferase reporter assays. Additionally, TAOK1 was predicted to be a downstream target of miRNA-942-5p, and the upregulation of TAOK1 due to linc00907 was reversed by miRNA-942-5p overexpression. linc00907 overexpression reduces apoptosis but can be reversed by TAOK1 knockdown. The reduction of TAOK1 counteracted the impact of linc00907 on gene expression associated with lipid metabolism and immunity, as well as on the accumulation of intracellular lipids.

conclusionsOur research suggests that linc00907 functions as a competitive endogenous RNA (ceRNA) by sequestering miRNA-942-5p, thus increasing the expression of TAOK1 and encouraging lipid accumulation in hepatocytes, leading to the aggravation of NASH development. Targeting the linc00907/miRNA-942-5p/TAOK1 axis may hold therapeutic potential for the treatment of NASH.

Indexed as

MicroRNAsNon-alcoholic Fatty Liver DiseaseRNA, Long NoncodingAnimalsDiet, High-FatDisease Models, AnimalDisease ProgressionHumansLipid MetabolismLiverMaleMiceMice, Inbred C57BLProtein Serine-Threonine KinasesMicroRNAsMIRN942 microRNA, humanProtein Serine-Threonine KinasesRNA, Long NoncodingTAO1 protein kinaselincRNA00907miRNA-942-5pNASHTAOK1

Identifiers

PMID38613803
PMCPMC11087098
OpenAlexW4394765531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.