ArticleAging2024
Age and aging process alter the gut microbes.
Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 5 citations in OpenAlex.
- Convergent Gut Microbiome Remodeling Across Ischemic Stroke, Myocardial Infarction, and Longevity Reveals a Shared Ecological Signature of Aging and Disease.International journal of molecular sciences · 2026Article
- Dynamic Changes in Gut Microbiota Composition and Function over Time in Suckling Raccoon Dogs.Animals : an open access journal from MDPI · 2026Article
- Targeting biological age with bioactive, microbiota-accessible nutritional complexes: a pilot study on healthspan extension in medically healthy adults.Scientific reports · 2025Article
- Sex-Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild-Based Analysis and Implications for Healthy Aging.Aging cell · 2025Article
- Polystyrene Accelerates Aging Related-Gut Microbiome Dysbiosis and -Metabolites in Old-Aged Mouse.Journal of microbiology and biotechnology · 2025Article
- The gut and circulating virome: emerging players in aging and longevity.Frontiers in aging · 2025Review
- Abnormalities in gut virome signatures linked with cognitive impairment in older adults.Gut microbesArticle
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGut microbes and age are both factors that influence the development of disease. The community structure of gut microbes is affected by age.
objectiveTo plot time-dependent gut microbe profiles in individuals over 45 years old and explore the correlation between age and gut microbes.
methodsFecal samples were collected from 510 healthy individuals over 45 years old. Shannon index, Simpson index, Ace index, etc. were used to analyze the diversity of gut microbes. The beta diversity analysis, including non-metric multidimensional scaling (NMDS), was used to analyze community distribution. Linear discriminant analysis (LDA) and random forest (RF) algorithm were used to analyze the differences of gut microbes. Trend analysis was used to plot the abundances of characteristic gut microbes in different ages.
resultsThe individuals aged 45-49 had the highest richness of gut bacteria. Fifteen characteristic gut microbes, including
conclusionsThe individuals in different ages have characteristic gut microbes. The changes in community structure of gut microbes may be related to age-induced diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.