Evidence map›Paper›PMID 38613792›Full record

ArticleAging2024

The coupling between healthspan and lifespan in

Stephen A Banse, E Grace Jackson, Christine A Sedore, Brian Onken, David Hall, Anna Coleman-Hulbert, Phu Huynh, Theo Garrett, Erik Johnson, Girish Harinath and 13 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Dopamine Abundance Uncouples Neurodegeneration and Lifespan in abioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Kinome-wide RNAi screening inJournal of biosciences · 2025
    Article
  12. Article
  13. Stochasticity in Dietary Restriction-Mediated Lifespan Outcomes inbioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. ConsideringCells · 2024
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 1 country.

Stephen A BanseInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
E Grace JacksonInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Christine A SedoreInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Brian OnkenDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
David HallThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Anna Coleman-HulbertInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Phu HuynhDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Theo GarrettThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Erik JohnsonInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Girish HarinathDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Delaney InmanThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Suzhen GuoDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Mackenzie MorsheadThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Jian XueDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Ron FalkowskiDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Esteban ChenDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Christopher HerreraDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Allie J KirschInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Viviana I PerezDivision of Aging Biology, National Institute on Aging, Bethesda, MD 20892, USA.
Max GuoDivision of Aging Biology, National Institute on Aging, Bethesda, MD 20892, USA.
Gordon J LithgowThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Monica DriscollDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Patrick C PhillipsInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Rutgers, The State University of New Jersey · USUniversity of Oregon · USBuck Institute for Research on Aging · USNational Institute on Aging · US

Funding

Discovering compounds with robust pro-longevity activitiesU01AG045844 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI Gordon J Lithgow · 2013 to 2026
$10.1M
Healthspan Analysis of C. elegans Strains Treated with Candidate Anti Aging InterU01AG045864 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI MONICA A. DRISCOLL · 2013 to 2026
$8.1M
Genetic variation underlying the response to longevity interventionsU01AG045829 · NIA · UNIVERSITY OF OREGON · PI Patrick C. Phillips · 2013 to 2026
$8.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Caenorhabditis Testing Program Data Coordinating CenterU24AG056052 · NIA · UNIVERSITY OF OREGON · PI Patrick C. Phillips · 2017 to 2026
$2.2M
NIA NIH HHS U01 AG045829NIA NIH HHS U01 AG045844NIA NIH HHS U01 AG045864NIA NIH HHS U24 AG056052NIH HHS P40 OD010440
6 · The paper itself

Abstract

Aging is characterized by declining health that results in decreased cellular resilience and neuromuscular function. The relationship between lifespan and health, and the influence of genetic background on that relationship, has important implications in the development of pharmacological anti-aging interventions. Here we assessed swimming performance as well as survival under thermal and oxidative stress across a nematode genetic diversity test panel to evaluate health effects for three compounds previously studied in the

Indexed as

Caenorhabditis elegansLongevityOxidative StressAgingAnimalsGenetic BackgroundPiperazinesResveratrolStilbenesSwimmingPiperazinesResveratrolStilbenesagingcompound interventiongenetic diversityhealthspan

Identifiers

PMID38613792
PMCPMC11042945
OpenAlexW4394786854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.