SynthesisEuropean geriatric medicine2024
Impact of frailty on pneumonia outcomes in older patients: a systematic review and meta-analysis.
Synthesis in European geriatric medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 5 citations in OpenAlex.
- Chinese Medicine Reduces Treatment Failure in Elderly Patients with Severe Community-Acquired Pneumonia: A Post-Hoc Analysis of a Randomized Controlled Trial.Chinese journal of integrative medicine · 2026Article
- Associations between biological age acceleration and hospitalization burden of community-acquired pneumonia: a cohort study.GeroScience · 2026Article
- Association of Frailty and Frailty Trajectory with Risk for Respiratory Infectious Diseases.Emerging infectious diseases · 2026Article
- Multi-dimensional risk prediction and genetic architecture of aspiration pneumonia: a population-based analysis.BMC infectious diseases · 2026Article
- Integrating the Hospital Frailty Risk Score into Explainable Machine Learning to Predict Mortality in Older Adults with Pneumonia: A Chilean Population-Based Study.Diagnostics (Basel, Switzerland) · 2026Article
- Predictors of secondary cardiovascular events in older adults with community-acquired pneumonia: a prospective observational study.Clinics (Sao Paulo, Brazil) · 2026Article
- Frailty as a Key Determinant of In-Hospital Mortality in 58,040 Patients with Community-Acquired Pneumonia: Evidence from a Chilean Cohort.Journal of clinical medicine · 2026Article
- Association between laboratory-based frailty index and unfavorable treatment outcomes in older adults with drug-susceptible pulmonary tuberculosis in the Republic of Korea: a retrospective cohort study.Frontiers in public health · 2026Article
- Treg/Th17 imbalance and its association with frailty in elderly patients with community-acquired pneumonia.Frontiers in medicine · 2026Article
- Association of frailty and malnutrition with pneumonia severity in PCV-13 vaccinated older adults: a single-centre experience.BMC geriatrics · 2025Article
- Frailty as a Predictor of Outcomes in Optiflow.Cureus · 2025Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe ideal method for identifying frailty remains unclear, but the condition is associated with poor prognoses in many illnesses. Despite the availability of studies, the prognostic implications of frailty on older patients with pneumonia remains unexplored. To determine the burden and effect of frailty on selected clinical outcomes among older patients with pneumonia.
methodsWe searched Medline, Google Scholar, and Science Direct databases for articles published in English following the PRISMA framework to guide our review. We included studies conducted on patients (> 60 years) with frailty and pneumonia, and reporting the effect of frailty on mortality, hospital stay, length readmission, and ICU admission. We performed a meta-analysis using STATA 14.2, calculating pooled odds ratios and 95% confidence intervals.
resultsWe analysed data from 16 studies and calculated a pooled frailty prevalence of 49% (95% CI 37-60%) in older patients with pneumonia. Unadjusted analyses revealed an odds ratio (OR) of 2.50 (95% CI 1.88-3.32) for the intermediate risk group, and an OR of 3.51 (95% CI 3.05-4.05) for the high risk group regarding mortality. The high risk frailty group also exhibited significant elevations in the risk of readmissions and extended hospital stay lengths. Substantial heterogeneity was observed in both adjusted and unadjusted analyses.
conclusionsOur systematic review and meta-analysis results show that one in every two older individuals with pneumonia present frailty, a condition that significantly influences their rates of mortality and readmission, and their hospital stay length.
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