Evidence map›Paper›PMID 38613174›Full record

ArticleVeterinary medicine and science2024

Establishment of the HPLC fluorescence detection method for plasma trace ivermectin and its pharmacokinetics in Bactrian camel.

Bin Hou, Haifeng Wang, Nan Jiang, Bilige Haosi, Surong Hasi

Open access · goldAbstract read
In one paragraph

Article in Veterinary medicine and science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Bin HouKey Laboratory of Clinical Diagnosis and Treatment Technology in Animal Diseases, Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.ORCID 0009-0004-5787-2376
Haifeng WangTongliao Institute of Agricultural and Animal Husbandry Sciences, Tongliao, China.
Nan JiangKey Laboratory of Clinical Diagnosis and Treatment Technology in Animal Diseases, Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
Bilige HaosiInner Mongolia Tenghetai Camel Industry Co., Ltd, Bayannur, China.
Surong HasiKey Laboratory of Clinical Diagnosis and Treatment Technology in Animal Diseases, Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
Inner Mongolia Agricultural University · CNHetao College · CNTongliao Academy of Agricultural Sciences · CN

Funding

Control Technology of Animal Diseases in Wushen BannerOrdos Science and Technology Plan 2022EEDSKJZDZX026
6 · The paper itself

Abstract

BACKGROUND AND

objectiveIvermectin (IVM), a widely used veterinary anthelmintic, lacks recommended doses for Bactrian camels. This study aims to establish its pharmacokinetics in Bactrian camels, comparing with other livestock.

methodsA method for high-performance liquid chromatography fluorescence detection of IVM in plasma was developed.

resultsIVM exhibited linear scaling (y = 0.6946x + 0.0088, R2 = 0.9988) within 0.025-5 ng/mL, with a lower limit of quantification of 25.00 pg/mL, high recovery (>70%) and low RSD (<7%). In Bactrian camels, IVM injection showed a low C

conclusionsSlow absorption and widespread distribution were observed, with peak concentration and area under the curve correlating positively with the dose. This study provides insights into IVM pharmacokinetics in Bactrian camels, informing dose determination and highlighting potential metabolic differences compared to other livestock.

Indexed as

CamelusIvermectinAnimalsCattleChromatography, High Pressure LiquidLivestockSheepIvermectinBactrian camelHPLC fluorescence detectionivermectin injectionpharmacokinetic characteristics

Identifiers

PMID38613174
PMCPMC11015068
OpenAlexW4394785648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.