Evidence map›Paper›PMID 38613125›Full record

ReviewNutrients2024

Biomarkers of Brain Dysfunction in Perinatal Iron Deficiency.

Raghavendra B Rao

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Raghavendra B RaoDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID 0000-0002-6089-5972
University of Minnesota Medical Center · US

Funding

STATISTICAL COREP01HD039386 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOZOFF, BETSY · 2001 to 2011
$14.0M
Detection and Correction of Iron Deficiency Induced Abnormal Brain MetabolismR01HD089989 · NICHD · UNIVERSITY OF MINNESOTA · PI COE, CHRISTOPHER L, GEORGIEFF, MICHAEL K. · 2017 to 2021
$2.7M
Novel Medical Food for Treating Infant Anemia and Iron Deficiency in the CNSR01HD080201 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI COE, CHRISTOPHER L · 2014 to 2018
$2.1M
Gestational Stress and Impaired Iron Homeostasis in the Young InfantR01HD057064 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI COE, CHRISTOPHER L · 2009 to 2013
$1.6M
NICHD NIH HHS P01 HD039386NICHD NIH HHS R01 HD057064NICHD NIH HHS R01 HD080201NICHD NIH HHS R01 HD089989NIH HHS HD089989
6 · The paper itself

Abstract

Iron deficiency in the fetal and neonatal period (perinatal iron deficiency) bodes poorly for neurodevelopment. Given its common occurrence and the negative impact on brain development, a screening and treatment strategy that is focused on optimizing brain development in perinatal iron deficiency is necessary. Pediatric societies currently recommend a universal iron supplementation strategy for full-term and preterm infants that does not consider individual variation in body iron status and thus could lead to undertreatment or overtreatment. Moreover, the focus is on hematological normalcy and not optimal brain development. Several serum iron indices and hematological parameters in the perinatal period are associated with a risk of abnormal neurodevelopment, suggesting their potential use as biomarkers for screening and monitoring treatment in infants at risk for perinatal iron deficiency. A biomarker-based screening and treatment strategy that is focused on optimizing brain development will likely improve outcomes in perinatal iron deficiency.

Indexed as

Brain DiseasesIron DeficienciesNeuromuscular DiseasesBiomarkersBrainChildFemaleHumansInfantInfant, NewbornInfant, PrematureIronPregnancyBiomarkersIronbiomarkerbrainferritinhemoglobinironiron deficiencyneurodevelopmentperinatalreticulocyte hemoglobinzinc protoporphyrin-to-heme ratio

Identifiers

PMID38613125
PMCPMC11013337
OpenAlexW4394566994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.