Evidence map›Paper›PMID 38613066›Full record

ArticleNutrients2024

Pre-Diagnosis Diet Predicts Response to Exclusive Enteral Nutrition and Correlates with Microbiome in Pediatric Crohn Disease.

Stephanie Dijk, Megan Jarman, Zhengxiao Zhang, Morgan Lawley, Muzammil Ahmad, Ricardo Suarez, Laura Rossi, Min Chen, Jessica Wu, Matthew W Carroll and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 11 institutions in 2 countries.

Stephanie DijkDepartment of Physiology, University of Alberta, Edmonton, AB T6G 1C9, Canada.ORCID 0000-0003-3178-0241
Megan JarmanDepartment of Agriculture, Life, & Environmental Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Zhengxiao ZhangDepartment of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0002-6977-4309
Morgan LawleyDivision of Pediatric Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Muzammil AhmadDivision of Pediatric Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Ricardo SuarezDivision of Pediatric Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Laura RossiFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada.
Min ChenNutrition Services (Child Health), Alberta Health Services, Edmonton, AB T5J 3E4, Canada.
Jessica WuNutrition Services (Child Health), Alberta Health Services, Edmonton, AB T5J 3E4, Canada.
Matthew W CarrollDivision of Pediatric Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0003-4237-0512
Anthony OtleyDivision of Gastroenterology & Nutrition, Department of Pediatrics, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Mary SherlockDivision of Gastroenterology and Nutrition, Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, Canada.
David R MackCHEO IBD Center, Department of Pediatrics, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Kevan JacobsonDivision of Gastroenterology, Hepatology and Nutrition, B.C. Children's Hospital, British Columbia Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.ORCID 0000-0001-7269-8557
Jennifer C deBruynSection of Pediatric Gastroenterology, Department of Pediatrics, University of Calgary, Calgary, AB T2N 1N4, Canada.
Wael El-MatarySection of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.ORCID 0000-0001-6417-7583
Colette DeslandresDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, CHU Sainte-Justine Hospital, Université de Montréal, Montréal, QC H3T 1J4, Canada.
Mohsin RashidDivision of Gastroenterology & Nutrition, Department of Pediatrics, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Peter C ChurchDivision of Pediatric Gastroenterology, IBD Center, Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1C6, Canada.
Thomas D WaltersDivision of Pediatric Gastroenterology, IBD Center, Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1C6, Canada.
Hien Q HuynhDivision of Pediatric Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Michael G SuretteFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada.
Anne M GriffithsDivision of Pediatric Gastroenterology, IBD Center, Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1C6, Canada.ORCID 0000-0001-8623-4665
Eytan WineDepartment of Physiology, University of Alberta, Edmonton, AB T6G 1C9, Canada.ORCID 0000-0002-3458-4142
Canadian Children IBD Network
University of Alberta · CAUniversity of Toronto · CAAlberta Health Services · CADalhousie University · CAPopulation Health Research Institute · CABC Children's Hospital · CACentre Hospitalier Universitaire Sainte-Justine · CAMcMaster University · CAUniversity of Calgary · CAUniversity of Manitoba · CAUniversity of Ottawa · CA

Funding

CIHR 426160
6 · The paper itself

Abstract

Exclusive enteral nutrition (EEN) is effective in inducing remission in pediatric Crohn disease (CD). EEN alters the intestinal microbiome, but precise mechanisms are unknown. We hypothesized that pre-diagnosis diet establishes a baseline gut microbiome, which then mediates response to EEN. We analyzed prospectively recorded food frequency questionnaires (FFQs) for pre-diagnosis dietary patterns. Fecal microbiota were sequenced (16SrRNA) at baseline and through an 18-month follow-up period. Dietary patterns, Mediterranean diet adherence, and stool microbiota were associated with EEN treatment outcomes, disease flare, need for anti-tumor necrosis factor (TNF)-α therapy, and long-term clinical outcomes. Ninety-eight patients were included. Baseline disease severity and microbiota were associated with diet. Four dietary patterns were identified by FFQs; a "mature diet" high in fruits, vegetables, and fish was linked to increased baseline microbial diversity, which was associated with fewer disease flares (

Indexed as

Crohn DiseaseDiet, MediterraneanMicrobiotaAnimalsChildEnteral NutritionHumansMaleTumor Necrosis Factor InhibitorsTumor Necrosis Factor Inhibitorsdietary patterninflammatory bowel diseasesmicrobiomenutritionpediatricsprediction

Identifiers

PMID38613066
PMCPMC11013084
OpenAlexW4393527353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.