Evidence map›Paper›PMID 38613039›Full record

ReviewNutrients2024

Gluten-Free Diet and Other Celiac Disease Therapies: Current Understanding and Emerging Strategies.

Anna Maria Mazzola, Irene Zammarchi, Maria Chiara Valerii, Enzo Spisni, Ilaria Maria Saracino, Francesco Lanzarotto, Chiara Ricci

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  5. Gluten-Free Cakes WithFood science & nutrition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Anna Maria MazzolaGastroenterology Unit, Spedali Civili Hospital, 25123 Brescia, Italy.
Irene ZammarchiGastroenterology Unit, Spedali Civili Hospital, 25123 Brescia, Italy.ORCID 0000-0002-3121-0639
Maria Chiara ValeriiUnit of Translational Physiology and Nutrition, Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126 Bologna, Italy.
Enzo SpisniUnit of Translational Physiology and Nutrition, Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-8525-2981
Ilaria Maria SaracinoMicrobiology Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.ORCID 0000-0003-4388-7089
Francesco LanzarottoGastroenterology Unit, Spedali Civili Hospital, 25123 Brescia, Italy.
Chiara RicciGastroenterology Unit, Spedali Civili Hospital, 25123 Brescia, Italy.ORCID 0000-0002-0748-6600
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Bologna · ITAzienda USL di Bologna · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A lifelong gluten-free diet (GFD) is the only treatment for celiac disease and other gluten-related disorders. Nevertheless, strict adherence to the GFD is often challenging due to concerns about social isolation, risk of gluten contaminations, high cost, poor quality and the taste of gluten-free products. Moreover, although the GFD is effective in achieving mucosal healing, it may lead to dietary imbalances due to nutrient deficiencies over a long period of time. To overcome these issues, several gluten-free wheat flours have been developed to create products that closely resemble their gluten-containing counterparts. Furthermore, given the critical importance of adhering to the GFD, it becomes essential to promote adherence and monitor possible voluntary or involuntary transgressions. Various methods, including clinical assessment, questionnaires, serology for celiac disease, duodenal biopsies and the detection of Gluten Immunogenic Peptides (GIPs) are employed for this purpose, but none are considered entirely satisfactory. Since adherence to the GFD poses challenges, alternative therapies should be implemented in the coming years to improve treatment efficacy and the quality of life of patients with celiac disease. The aim of this narrative review is to explore current knowledge of the GFD and investigate its future perspectives, focusing on technology advancements, follow-up strategies and insights into a rapidly changing future.

Indexed as

Celiac DiseaseDiet, Gluten-FreeBiopsyGlutensHumansQuality of LifeGlutensadherencecontaminationgluten-free dietnutritionpsychological aspects

Identifiers

PMID38613039
PMCPMC11013189
OpenAlexW4393356393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.