Evidence map›Paper›PMID 38613008›Full record

Trial reportNutrients2024

The Effect of Sn-2 Palmitate on Blood Glucose, Lipids and Body Composition in Middle-Aged and Elderly Adults: A Randomized, Double-Blinded Controlled Trial.

Wuxian Zhong, Ai Zhao, Xuetao Wei, Shuai Mao, Pin Li, Qianqian Shen, Hong Zhang, Hua Jiang, Peiyu Wang, Yumei Zhang

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wuxian ZhongDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.ORCID 0000-0003-0741-8496
Ai ZhaoVanke School of Public Health, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-1679-973X
Xuetao WeiDepartment of Toxicology, School of Public Health, Peking University, Beijing 100191, China.
Shuai MaoDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Pin LiDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.ORCID 0000-0003-3164-8806
Qianqian ShenDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Hong ZhangWilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd., Shanghai 200137, China.ORCID 0000-0001-7998-8696
Hua JiangSchool of Nursing, Peking University, Beijing 100191, China.ORCID 0000-0002-3264-990X
Peiyu WangDepartment of Social Medicine and Health Education, School of Public Health, Peking University, Beijing 100191, China.
Yumei ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.ORCID 0000-0002-0103-7900

Funding

Chinese Nutrition Society National Nutrition Science Research Grant CNS-W2018A46Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd. and National Key Research and Development Program of China 2022YFD2101501
6 · The paper itself

Abstract

Sn-2 palmitate is widely used in infant formula. However, little is known about its effects on metabolism and body composition in middle-aged and elderly adults. In a double-blinded, randomized controlled trial, we enrolled Chinese adults aged 45-75 years with self-reported constipation. Individuals were randomly assigned in a 1:1 ratio to a 1,3-dioleoyl-2-palmitoyl-glycerol (OPO)-enriched oil (66% palmitic acid in the sn-2 position) or a control vegetable oil (24% palmitic acid in the sn-2 position) daily for 24 weeks. Skim milk powder was used as the carrier for both fats. Interviews and body composition were performed at baseline, week 4, week 12 and week 24. A fasting blood draw was taken except at week 4. This study was a secondary analysis and considered exploratory. A total of 111 adults (83 women and 28 men, mean age 64.2 ± 7.0 years) were enrolled, of whom 53 were assigned to the OPO group and 57 to the control group. During the intervention, blood glucose, triglyceride, the triglyceride-glucose index, total cholesterol, low-density lipoprotein cholesterol and remnant cholesterol remained stable, while high-density lipoprotein cholesterol decreased in both groups (

Indexed as

Blood GlucosePalmitatesAgedBody CompositionChinaCholesterol, HDLEast Asian PeopleFemaleHumansMaleMiddle AgedPalmitic AcidPlant OilsTriglyceridesBlood GlucoseCholesterol, HDLPalmitatesPalmitic AcidPlant OilsTriglyceridesbody compositionglucosehigh-density lipoprotein cholesterollow-density lipoprotein cholesterolpalmitic acidskeletal muscle mass indexsn-2 palmitate

Identifiers

PMID38613008
PMCPMC11013204

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.