Evidence map›Paper›PMID 38612993›Full record

SynthesisNutrients2024

Association of Gut Microbiota-Related Metabolites and Type 2 Diabetes in Two Puerto Rican Cohorts.

Caleigh M Sawicki, Lorena S Pacheco, Sona Rivas-Tumanyan, Zheyi Cao, Danielle E Haslam, Liming Liang, Katherine L Tucker, Kaumudi Joshipura, Shilpa N Bhupathiraju

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Caleigh M SawickiChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA.
Lorena S PachecoDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-0569-9506
Sona Rivas-TumanyanDepartment of Surgical Sciences, School of Dental Medicine, University of Puerto Rico, San Juan, PR 00921, USA.ORCID 0000-0002-3773-7028
Zheyi CaoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0009-0009-1667-0213
Danielle E HaslamChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA.ORCID 0000-0003-0144-3287
Liming LiangDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Katherine L TuckerDepartment of Biomedical and Nutritional Sciences and Center for Population Health, University of Massachusetts, Lowell, MA 01854, USA.ORCID 0000-0001-7640-662X
Kaumudi JoshipuraDepartment of Surgical Sciences, School of Dental Medicine, University of Puerto Rico, San Juan, PR 00921, USA.
Shilpa N BhupathirajuChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA.
Brigham and Women's Hospital · USHarvard University · USUniversity of Puerto Rico System · PRUniversity of Massachusetts Lowell · US

Funding

Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
STATISTICSP50HL105185 · NHLBI · UNIVERSITY OF MASSACHUSETTS LOWELL · PI TUCKER, KATHERINE L · 2010 to 2015
$10.4M
Center for Research/Nutrition &Health among the ElderlyP01AG023394 · NIA · TUFTS UNIVERSITY BOSTON · PI TUCKER, KATHERINE L · 2003 to 2007
$8.1M
TRAINING GRANT IN ACADEMIC NUTRITIONT32DK007703 · NIDDK · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTOPHER P DUGGAN, Frank B Hu · 1994 to 2026
$7.8M
Periodontitis and pre-clinical diabetesR01DE020111 · NIDCR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI JOSHIPURA, KAUMUDI J, PEREZ, CYNTHIA MADELINE · 2010 to 2015
$3.1M
Saliva and Plasma Metabolomic Signatures of Diabetes Progression in a Hispanic CohortR01DK120560 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI BHUPATHIRAJU, SHILPA NANDANA · 2019 to 2023
$2.3M
Proteomic and integrative omic profiles of sugar- and artificially sweetened beverage consumption and changes in type 2 diabetes risk factorsK01DK136968 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Danielle Haslam · 2023 to 2026
$634k
A Culturally-Adapted Multicomponent Teaching Kitchen Intervention for Low-Income Latino AdultsK01HL169414 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorena Sonia Pacheco · 2023 to 2026
$557k
NCI NIH HHS T32 CA009001NHLBI NIH HHS K01 HL169414NHLBI NIH HHS P50 HL105185NIA NIH HHS P01 AG023394NIDCR NIH HHS R01 DE020111NIDDK NIH HHS K01 DK136968NIDDK NIH HHS R01 DK120560NIDDK NIH HHS T32 DK007703
6 · The paper itself

Abstract

(1) Aims: Gut microbiota metabolites may play integral roles in human metabolism and disease progression. However, evidence for associations between metabolites and cardiometabolic risk factors is sparse, especially in high-risk Hispanic populations. We aimed to evaluate the cross-sectional and longitudinal relationships between gut microbiota related metabolites and measures of glycemia, dyslipidemia, adiposity, and incident type 2 diabetes in two Hispanic observational cohorts. (2) Methods: We included data from 670 participants of the Boston Puerto Rican Health Study (BPRHS) and 999 participants of the San Juan Overweight Adult Longitudinal Study (SOALS). Questionnaires and clinical examinations were conducted over 3 years of follow-up for SOALS and 6 years of follow-up for BPRHS. Plasma metabolites, including L-carnitine, betaine, choline, and trimethylamine

Indexed as

Diabetes Mellitus, Type 2Gastrointestinal MicrobiomeHispanic or LatinoMethylaminesAdultBetaineBostonCarnitineCholineCross-Sectional StudiesGlucoseGlycated HemoglobinHumansLongitudinal StudiesPuerto RicoBetaineCarnitineCholineGlucoseGlycated HemoglobinMethylaminestrimethyloxaminebetainecardiometabolic risk factorsglycemiagut microbiota metabolitesPuerto Ricantype 2 diabetes

Identifiers

PMID38612993
PMCPMC11013596
OpenAlexW4393218414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.