Evidence map›Paper›PMID 38612969›Full record

ArticleNutrients2024

Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy.

Suzanne A Alvernaz, Elizabeth S Wenzel, Unnathi Nagelli, Lacey B Pezley, Bazil LaBomascus, Jack A Gilbert, Pauline M Maki, Lisa Tussing-Humphreys, Beatriz Peñalver Bernabé

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Suzanne A AlvernazDepartment of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USA.ORCID 0000-0002-8370-5537
Elizabeth S WenzelDepartment of Psychology, University of Illinois, Chicago, IL 60607, USA.
Unnathi NagelliDepartment of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USA.
Lacey B PezleyDepartment of Kinesiology and Nutrition, University of Illinois, Chicago, IL 60612, USA.ORCID 0000-0003-3385-8460
Bazil LaBomascusDepartment of Kinesiology and Nutrition, University of Illinois, Chicago, IL 60612, USA.
Jack A GilbertDepartment of Pediatrics, University of California, San Diego, CA 92093, USA.ORCID 0000-0001-7920-7001
Pauline M MakiDepartment of Psychology, University of Illinois, Chicago, IL 60607, USA.
Lisa Tussing-HumphreysDepartment of Kinesiology and Nutrition, University of Illinois, Chicago, IL 60612, USA.
Beatriz Peñalver BernabéDepartment of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USA.
University of Illinois Chicago · USScripps Institution of Oceanography · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
The UCSD Microbiome and Metagenomics Center (Summit Supplement)U24DK131617 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jack Anthony Gilbert, ROB KNIGHT · 2022 to 2026
$15.3M
UIC Building Interdisciplinary Research Careers in Women's Health ProgramK12HD101373 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BUHIMSCHI, IRINA A, MAKI, PAULINE M · 2020 to 2023
$2.9M
Human Microbiome and Perinatal DepressionR03HD095056 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GILBERT, JACK ANTHONY, MAKI, PAULINE M · 2018 to 2019
$176k
NCATS NIH HHS UL1 TR002003NICHD NIH HHS K12 HD101373NICHD NIH HHS R03 HD095056NIDDK NIH HHS U24 DK131617NIH HHS 1U24DK131617-01NIH HHS K12HD101373NIH HHS R03HD095056
6 · The paper itself

Abstract

Pregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter the host immune system to promote inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbial dysbiosis, including gestational diabetes mellitus, pre-eclampsia, preterm birth, and mood disorders. However, the effects of high-inflammatory diets on the gut microbiota during pregnancy have yet to be fully explored. We aimed to address this gap using a system-based approach to characterize associations among dietary inflammatory potential, a measure of diet quality, and the gut microbiome during pregnancy. Forty-seven pregnant persons were recruited prior to 16 weeks of gestation. Participants completed a food frequency questionnaire (FFQ) and provided fecal samples. Dietary inflammatory potential was assessed using the Dietary Inflammatory Index (DII) from the FFQ data. Fecal samples were analyzed using 16S rRNA amplicon sequencing. Differential taxon abundances with respect to the DII score were identified, and the microbial metabolic potential was predicted using PICRUSt2. Inflammatory diets were associated with decreased vitamin and mineral intake and a dysbiotic gut microbiota structure and predicted metabolism. Gut microbial compositional differences revealed a decrease in short-chain fatty acid producers such as

Indexed as

AvitaminosisGastrointestinal MicrobiomePremature BirthDietDysbiosisFemaleHumansInfant, NewbornInflammationPregnancyRNA, Ribosomal, 16SVitaminsRNA, Ribosomal, 16SVitaminsdietdietary inflammatory indexfood frequency questionnairegalactosegut microbiotainflammationpregnancy

Identifiers

PMID38612969
PMCPMC11013194
OpenAlexW4393141973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.