Evidence map›Paper›PMID 38612864›Full record

ArticleInternational journal of molecular sciences2024

Biosynthesis of Hesperetin, Homoeriodictyol, and Homohesperetin in a Transcriptomics-Driven Engineered Strain of

Álvaro Pérez-Valero, Juan Serna-Diestro, Albert Tafur Rangel, Simona Barbuto Ferraiuolo, Chiara Schiraldi, Eduard J Kerkhoven, Claudio J Villar, Felipe Lombó

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Álvaro Pérez-ValeroResearch Group BIONUC (Biotechnology of Nutraceuticals and Bioactive Compounds), Area of Microbiology, Department of Functional Biology, University of Oviedo, 33006 Oviedo, Principality of Asturias, Spain.ORCID 0000-0002-4560-3847
Juan Serna-DiestroResearch Group BIONUC (Biotechnology of Nutraceuticals and Bioactive Compounds), Area of Microbiology, Department of Functional Biology, University of Oviedo, 33006 Oviedo, Principality of Asturias, Spain.ORCID 0000-0003-1820-8064
Albert Tafur RangelDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.ORCID 0000-0002-9428-183X
Simona Barbuto FerraiuoloSection of Biotechnology and Molecular Biology, Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio 7, 80138 Naples, Italy.ORCID 0000-0002-9126-5869
Chiara SchiraldiSection of Biotechnology and Molecular Biology, Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio 7, 80138 Naples, Italy.ORCID 0000-0002-1066-843X
Eduard J KerkhovenDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.ORCID 0000-0002-3593-5792
Claudio J VillarResearch Group BIONUC (Biotechnology of Nutraceuticals and Bioactive Compounds), Area of Microbiology, Department of Functional Biology, University of Oviedo, 33006 Oviedo, Principality of Asturias, Spain.
Felipe LombóResearch Group BIONUC (Biotechnology of Nutraceuticals and Bioactive Compounds), Area of Microbiology, Department of Functional Biology, University of Oviedo, 33006 Oviedo, Principality of Asturias, Spain.ORCID 0000-0002-6680-6723
Universidad de Oviedo · ESUniversity of Campania "Luigi Vanvitelli" · ITNovo Nordisk Foundation · DKScience for Life Laboratory · SE

Funding

European Union 814650Gobierno del Principado de Asturias AYUD/2021/51347Gobierno del Principado de Asturias PA-21-PF-BP20-150Ministerio de Ciencia e Innovación PID2021-127812OB-I00Ministerio de Ciencia e Innovación PRE2022-102792
6 · The paper itself

Abstract

Flavonoids exhibit various bioactivities including anti-oxidant, anti-tumor, anti-inflammatory, and anti-viral properties. Methylated flavonoids are particularly significant due to their enhanced oral bioavailability, improved intestinal absorption, and greater stability. The heterologous production of plant flavonoids in bacterial factories involves the need for enough biosynthetic precursors to allow for high production levels. These biosynthetic precursors are malonyl-CoA and l-tyrosine. In this work, to enhance flavonoid biosynthesis in

Indexed as

Craniofacial AbnormalitiesFlavonesFlavonoidsGene Expression ProfilingHesperidinStreptomycesAmino AcidsTyrosineAmino AcidsFlavonesFlavonoidshesperetinHesperidinhomoeriodictyolTyrosineflavonoidl-tyrosine feedingmethyltransferasesubstrate flexibility

Identifiers

PMID38612864
PMCPMC11012174
OpenAlexW4393993066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.