Evidence map›Paper›PMID 38612857›Full record

ArticleInternational journal of molecular sciences2024

Complement MASP-1 Modifies Endothelial Wound Healing.

Zsuzsanna Németh, Flóra Demeter, József Dobó, Péter Gál, László Cervenak

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zsuzsanna NémethDepartment of Internal Medicine and Haematology, Semmelweis University, 1085 Budapest, Hungary.
Flóra DemeterDepartment of Internal Medicine and Haematology, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0003-0149-2871
József DobóInstitute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Hungarian Research Network, 1117 Budapest, Hungary.ORCID 0000-0001-9187-8502
Péter GálInstitute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Hungarian Research Network, 1117 Budapest, Hungary.ORCID 0000-0001-8987-2080
László CervenakDepartment of Internal Medicine and Haematology, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0003-0166-8697
Semmelweis University · HUHUN-REN Research Centre for Natural Sciences · HU

Funding

European Union - 2020-1.1.2-PIACI-KFI-2021-00273 RRF-2.3.1-21-2022-00015European Union-Next Generation EU. Project TKP2021-EGA-24 (MOLORKIV)National Research, Development and Innovation Office K115623National Research, Development and Innovation Office K134711
6 · The paper itself

Abstract

Endothelial wound-healing processes are fundamental for the maintenance and restoration of the circulatory system and are greatly affected by the factors present in the blood. We have previously shown that the complement protein mannan-binding lectin-associated serine protease-1 (MASP-1) induces the proinflammatory activation of endothelial cells and is able to cooperate with other proinflammatory activators. Our aim was to investigate the combined effect of mechanical wounding and MASP-1 on endothelial cells. Transcriptomic analysis showed that MASP-1 alters the expression of wound-healing-related and angiogenesis-related genes. Both wounding and MASP-1 induced Ca

Indexed as

Endothelial CellsMannose-Binding Protein-Associated Serine ProteasesComplement System ProteinsVascular Cell Adhesion Molecule-1Wound HealingComplement System ProteinsMannose-Binding Protein-Associated Serine ProteasesVascular Cell Adhesion Molecule-1adhesion moleculesangiogenesisCa2+ responseCREB phosphorylationendothelial cellMASP-1Matrigel®wound healing

Identifiers

PMID38612857
PMCPMC11012537
OpenAlexW4393992945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.