Evidence map›Paper›PMID 38612853›Full record

ArticleInternational journal of molecular sciences2024

Thermosensitive TRP Channels Are Functionally Expressed and Influence the Lipogenesis in Human Meibomian Gland Cells.

Melina Keller, Stefan Mergler, Aruna Li, Ingrid Zahn, Friedrich Paulsen, Fabian Garreis

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Melina KellerDepartment of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsstraße 19, 91054 Erlangen, Germany.
Stefan MerglerDepartment of Ophthalmology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13353 Berlin, Germany.ORCID 0000-0001-8608-648X
Aruna LiDepartment of Ophthalmology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13353 Berlin, Germany.
Ingrid ZahnDepartment of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsstraße 19, 91054 Erlangen, Germany.ORCID 0000-0002-6477-4940
Friedrich PaulsenDepartment of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsstraße 19, 91054 Erlangen, Germany.ORCID 0000-0002-0527-0953
Fabian GarreisDepartment of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsstraße 19, 91054 Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEHumboldt-Universität zu Berlin · DE

Funding

Deutsche Forschungsgemeinschaft ME 1706/18-1Deutsche Forschungsgemeinschaft PA738/15-1Deutsche Ophthalmologische Gesellschaft DoktorandenstipendiumErnst-Muck Foundation research grant
6 · The paper itself

Abstract

While the involvement of thermosensitive transient receptor potential channels (TRPs) in dry eye disease (DED) has been known for years, their expression in the meibomian gland (MG) has never been investigated. This study aims to show their expression and involvement in the lipogenesis of the MG, providing a possible new drug target in the treatment of DED. Our RT-PCR, Western blot and immunofluorescence analysis showed the expression of

Indexed as

Meibomian Gland DysfunctionMeibomian GlandsBlotting, WesternCapsaicinHumansLipogenesisCapsaicindry eye diseasemeibomian glandmeibomian gland dysfunctiontear filmthermo-TRPsTRP channels

Identifiers

PMID38612853
PMCPMC11012639
OpenAlexW4393992393

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.