Evidence map›Paper›PMID 38612725›Full record

Trial reportInternational journal of molecular sciences2024

The Predictive Role of Serum Lipid Levels, p53 and ki-67, According to Molecular Subtypes in Breast Cancer: A Randomized Clinical Study.

Ionut Flaviu Faur, Amadeus Dobrescu, Ioana Adelina Clim, Paul Pasca, Catalin Prodan-Barbulescu, Cristi Tarta, Andreea-Adriana Neamtu, Dan Brebu, Carmen Neamtu, Mihai Rosu and 4 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Intraoperative radiation therapy (IORT) in Taiwanese breast cancer patients: factors influencing local relapse risk and disease-free survival.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Ionut Flaviu FaurIInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania.ORCID 0000-0001-6451-7461
Amadeus DobrescuIInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania.ORCID 0000-0001-5736-572X
Ioana Adelina ClimIInd Obstetrics and Gynecology Clinic "Dominic Stanca", 400124 Cluj-Napoca, Romania.
Paul PascaIInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania.
Catalin Prodan-BarbulescuFaculty of Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.ORCID 0000-0003-4348-5469
Cristi TartaIInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania.ORCID 0000-0003-1772-3910
Andreea-Adriana NeamtuFaculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq., Nr. 2, 300041 Timișoara, Romania.ORCID 0000-0002-5219-5466
Dan BrebuIInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania.
Carmen NeamtuIst Clinic of General Surgery, Arad County Emergency Clinical Hospital, 310158 Arad, Romania.ORCID 0000-0002-4766-5945
Mihai RosuIst Clinic of General Surgery, Arad County Emergency Clinical Hospital, 310158 Arad, Romania.
Ciprian DutaIInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania.
Andreea ClimDepartment of Morpho-Functional Sciences II, Discipline of Physiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Gabriel LazarDepartment of Oncology Surgery, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.
Bogdan TotoliciIst Clinic of General Surgery, Arad County Emergency Clinical Hospital, 310158 Arad, Romania.
Victor Babeș University of Medicine and Pharmacy Timișoara · ROArad County Clinical Hospital · ROGrigore T. Popa University of Medicine and Pharmacy · ROIuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dyslipidemia is a component of metabolic syndrome, having an important role in the carcinogenesis of different tumor types, such as prostate, ovarian, or renal cancer. The number of studies on the predictive potential of the different components of the lipid profile with a predictive potential in breast cancer is quite low. The evaluation of the lipid profile was carried out for the 142 patients who benefited from neoadjuvant therapy (NAC) in order to identify a potential predictive biomarker. The serological sample collection was performed sequentially according to a standardized protocol, pre-NAC, post-NAC and 6 months post-NAC after a 6-h pre-collection fast. We also investigated in the general group the presence or absence of the p53 mutation (TP53) and of the mitotic index ki-67, respectively, in relation to the molecular subtypes. The menopausal status, tumor size, family history, grading, Ki-67, p53 and LN metastases have a predictive nature regarding overall survival (OS) (

Indexed as

Kidney NeoplasmsTriple Negative Breast NeoplasmsCholesterol, LDLHumansKi-67 AntigenMaleTumor Suppressor Protein p53Cholesterol, LDLKi-67 AntigenTumor Suppressor Protein p53biomarkerBRCAHDL-CKI-67molecular subtypeneoadjuvant therapyp53

Identifiers

PMID38612725
PMCPMC11012133
OpenAlexW4393356586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.