Evidence map›Paper›PMID 38612707›Full record

ArticleInternational journal of molecular sciences2024

Reprogramming Chromosome Ends by Functional Histone Acetylation.

W Alex Meltzer, Aditi Gupta, Phyo Nay Lin, Robert A Brown, Daniel S Benyamien-Roufaeil, Raju Khatri, Anup A Mahurkar, Yang Song, Rodney J Taylor, Michal Zalzman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

W Alex MeltzerDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Aditi GuptaDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Phyo Nay LinDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-4041-629X
Robert A BrownDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Daniel S Benyamien-RoufaeilDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Raju KhatriDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-1381-8560
Anup A MahurkarInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yang SongInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Rodney J TaylorDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Michal ZalzmanDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-4689-2951
University of Maryland, Baltimore · US

Funding

Enhancing the potency of aged adult stem cells for tissue reconstructionR01AR070819 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI ZALZMAN, MICHAL · 2017 to 2021
$1.7M
NIAMS NIH HHS R01 AR070819NIAMS NIH HHS R01AR070819
6 · The paper itself

Abstract

Cancers harness embryonic programs to evade aging and promote survival. Normally, sequences at chromosome ends called telomeres shorten with cell division, serving as a countdown clock to limit cell replication. Therefore, a crucial aspect of cancerous transformation is avoiding replicative aging by activation of telomere repair programs. Mouse embryonic stem cells (mESCs) activate a transient expression of the gene

Indexed as

HistonesTelomereAcetylationAgingAnimalsChromatinHumansMiceChromatinHistonescancerCRISPRepigeneticshistone acetylationnext-gen sequencingover-expressionpluripotencystem cellstelomeresZSCAN4

Identifiers

PMID38612707
PMCPMC11011970
OpenAlexW4393356602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.