Evidence map›Paper›PMID 38612694›Full record

ArticleInternational journal of molecular sciences2024

The mRNA-Binding Protein KSRP Limits the Inflammatory Response of Macrophages.

Vanessa Bolduan, Kim-Alicia Palzer, Christoph Hieber, Jenny Schunke, Michael Fichter, Paul Schneider, Stephan Grabbe, Andrea Pautz, Matthias Bros

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The RNA-binding protein KSRP reduces asthma-like characteristics in a murine model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Vanessa BolduanDepartment of Dermatology, University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.
Kim-Alicia PalzerDepartment of Pharmacology, University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.
Christoph HieberDepartment of Dermatology, University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.
Jenny SchunkeDepartment of Dermatology, University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.
Michael FichterDepartment of Dermatology, University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.
Paul SchneiderDepartment of Dermatology, University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.
Stephan GrabbeDepartment of Dermatology, University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.ORCID 0000-0002-6863-8719
Andrea PautzDepartment of Pharmacology, University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.ORCID 0000-0003-3969-0056
Matthias BrosDepartment of Dermatology, University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany.
Johannes Gutenberg University Mainz · DE

Funding

Deutsche Forschungsgemeinschaft BR 3880/4-1, PA 1933/7-1, PA 1933/2-3
6 · The paper itself

Abstract

KH-type splicing regulatory protein (KSRP) is a single-stranded nucleic acid-binding protein with multiple functions. It is known to bind AU-rich motifs within the 3'-untranslated region of mRNA species, which in many cases encode dynamically regulated proteins like cytokines. In the present study, we investigated the role of KSRP for the immunophenotype of macrophages using bone marrow-derived macrophages (BMDM) from wild-type (WT) and KSRP

Indexed as

Carrier ProteinsInterleukin-63' Untranslated RegionsAnimalsCytokinesLipopolysaccharidesMacrophagesMice3' Untranslated RegionsCarrier ProteinsCytokinesInterleukin-6LipopolysaccharideschemokinescytokinesKSRPLPS-induced sepsismacrophagesRNA-binding proteins

Identifiers

PMID38612694
PMCPMC11011855
OpenAlexW4393353239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.