Evidence map›Paper›PMID 38612562›Full record

ArticleInternational journal of molecular sciences2024

IL-17RA Signaling in Prx1+ Mesenchymal Cells Influences Fracture Healing in Mice.

Joseph L Roberts, David Kapfhamer, Varsha Devarapalli, Hicham Drissi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joseph L RobertsDepartment of Orthopaedics, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0001-6839-1173
David KapfhamerDepartment of Orthopaedics, Emory University, Atlanta, GA 30329, USA.
Varsha DevarapalliDepartment of Orthopaedics, Emory University, Atlanta, GA 30329, USA.
Hicham DrissiDepartment of Orthopaedics, Emory University, Atlanta, GA 30329, USA.
Emory University · US

Funding

Osteogenic and angiogenic tissue regeneration to accelerate secondary bone healing during agingR01AG064464 · NIA · EMORY UNIVERSITY · PI DRISSI, MOULAY HICHAM · 2019 to 2023
$1.3M
NIA NIH HHS R01 AG064464NIH HHS R01AG064464
6 · The paper itself

Abstract

Fracture healing is a complex series of events that requires a local inflammatory reaction to initiate the reparative process. This inflammatory reaction is important for stimulating the migration and proliferation of mesenchymal progenitor cells from the periosteum and surrounding tissues to form the cartilaginous and bony calluses. The proinflammatory cytokine interleukin (IL)-17 family has gained attention for its potential regenerative effects; however, the requirement of IL-17 signaling within mesenchymal progenitor cells for normal secondary fracture healing remains unknown. The conditional knockout of IL-17 receptor a (

Indexed as

Femoral FracturesHomeodomain ProteinsMesenchymal Stem CellsReceptors, Interleukin-17AnimalsFracture HealingInflammationMiceOsteogenesisX-Ray MicrotomographyHomeodomain ProteinsIl17ra protein, mousePrrx1 protein, mouseReceptors, Interleukin-17cytokineIL-17Ainflammationperiosteumsecondary bone healing

Identifiers

PMID38612562
PMCPMC11011315
OpenAlexW4393255243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.