Evidence map›Paper›PMID 38612527›Full record

ArticleInternational journal of molecular sciences2024

Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.

Irene Portolés, Jordi Ribera, Esther Fernandez-Galán, Elena Lecue, Gregori Casals, Pedro Melgar-Lesmes, Guillermo Fernández-Varo, Loreto Boix, Marco Sanduzzi, Veenu Aishwarya and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Irene PortolésBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), 170 Villarroel St. Barcelona, 08036 Barcelona, Spain.
Jordi RiberaBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), 170 Villarroel St. Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-0288-4220
Esther Fernandez-GalánBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), 170 Villarroel St. Barcelona, 08036 Barcelona, Spain.ORCID 0000-0001-9128-1968
Elena LecueBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), 170 Villarroel St. Barcelona, 08036 Barcelona, Spain.
Gregori CasalsBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), 170 Villarroel St. Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-3271-1371
Pedro Melgar-LesmesBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), 170 Villarroel St. Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-2009-5911
Guillermo Fernández-VaroBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), 170 Villarroel St. Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-7776-3300
Loreto BoixCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28222 Madrid, Spain.
Marco SanduzziCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28222 Madrid, Spain.
Veenu AishwaryaAUM LifeTech, Inc., 3675 Market Street, Suite 200, Philadelphia, PA 19104, USA.
Maria ReigCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28222 Madrid, Spain.ORCID 0000-0002-5711-9534
Wladimiro JiménezBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), 170 Villarroel St. Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-9376-0214
Manuel Morales-RuizBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), 170 Villarroel St. Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-9074-2272
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESFundació Clínic per a la Recerca Biomèdica · ES

Funding

Agencia Estatal de Investigación MCIN/AEI/10.13039/501100011033/FEDER UEAgencia Estatal de Investigación PID2022-138243OB-I00Consolidated Research Group, Departament de Recerca I Universitats de la Generalitat de Catalunya 2021 SGR 00881FSE "El FSE invierte en tu futuro" BES-2017-080823Instituto de Salud Carlos III FI19/00222Instituto de Salud Carlos III PI15/00145Instituto de Salud Carlos III PI18/00768Instituto de Salud Carlos III PI18/0358Ministerio de Ciencia e Innovación PID2021-123426OB-I00Programa Estatal del Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023 RedFibro RED2022-134485-TRamon y Cajal Program RYC2018-0Z23971-I
6 · The paper itself

Abstract

RNA helicase DHX15 plays a significant role in vasculature development and lung metastasis in vertebrates. In addition, several studies have demonstrated the overexpression of DHX15 in the context of hepatocellular carcinoma. Therefore, we hypothesized that this helicase may play a significant role in liver regeneration, physiology, and pathology.

Indexed as

Carcinoma, HepatocellularRNA HelicasesZebrafishZebrafish ProteinsAnimalsHumansMiceOligonucleotidesDhx15 protein, mousedhx15 protein, zebrafishOligonucleotidesRNA HelicasesZebrafish Proteinsglucose metabolismhepatocellular carcinomaliver organogenesisliver regenerationRNA helicase

Identifiers

PMID38612527
PMCPMC11011938
OpenAlexW4393218643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.