Evidence map›Paper›PMID 38612519›Full record

ArticleInternational journal of molecular sciences2024

Gene Silencing of Angiopoietin-like 3 (ANGPTL3) Induced De Novo Lipogenesis and Lipid Accumulation in Huh7 Cell Line.

Ilaria Rossi, Giorgia Marodin, Maria Giovanna Lupo, Maria Pia Adorni, Bianca Papotti, Stefano Dall'Acqua, Nicola Ferri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Molecular Regulation and Therapeutic Targeting of VLDL Production in Cardiometabolic Disease.Cellular and molecular gastroenterology and hepatology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ilaria RossiDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-2788-8471
Giorgia MarodinDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.ORCID 0009-0008-2626-625X
Maria Giovanna LupoDepartment of Medicine, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-4236-4414
Maria Pia AdorniDepartment of Medicine and Surgery, University of Parma, Via Volturno 39/F, 43125 Parma, Italy.ORCID 0000-0002-4810-6862
Bianca PapottiDepartment of Food and Drug, University of Parma, Viale delle Scienze 27/A, 43124 Parma, Italy.
Stefano Dall'AcquaDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0001-8264-6953
Nicola FerriDepartment of Medicine, University of Padova, 35128 Padova, Italy.ORCID 0000-0001-8898-7441
University of Padua · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiopoietin-like 3 (ANGPTL3) is a hepatokine acting as a negative regulator of lipoprotein lipase (LPL). Vupanorsen, an

Indexed as

LipogenesisProprotein Convertase 9Angiopoietin-Like Protein 3AngiopoietinsCholesterolCoenzyme AGene SilencingHumansRNA, Small InterferingSubtilisinsAngiopoietin-Like Protein 3AngiopoietinsANGPTL3 protein, humanCholesterolCoenzyme APCSK9 protein, humanProprotein Convertase 9RNA, Small InterferingSubtilisinsANGPTL3de novo lipogenesislipidsPCSK9vupanorsen

Identifiers

PMID38612519
PMCPMC11011473
OpenAlexW4393188597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.