Evidence map›Paper›PMID 38612454›Full record

ArticleInternational journal of molecular sciences2024

Biochemical Fractionation of Human α-Synuclein in a

Khondamir Imomnazarov, Joshua Lopez-Scarim, Ila Bagheri, Valerie Joers, Malú Gámez Tansey, Alfonso Martín-Peña

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Khondamir ImomnazarovCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.ORCID 0009-0007-0808-7808
Joshua Lopez-ScarimCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Ila BagheriCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.ORCID 0009-0009-0624-4536
Valerie JoersCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-6743-6587
Malú Gámez TanseyCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Alfonso Martín-PeñaCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
University of Florida · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
BIOPTERIN &CATECHOLAMINES IN AGING &NEURO-DEGENERATIONR01NS028800 · NINDS · HENRY FORD HEALTH SYSTEM · PI LEVINE, ROBERT A · 1992 to 1995
–
Alzheimer's Association AARG-D-22-972117NIH HHS 1RF1NS28800NIH HHS P40 OD018537
6 · The paper itself

Abstract

Synucleinopathies are a group of central nervous system pathologies that are characterized by the intracellular accumulation of misfolded and aggregated α-synuclein in proteinaceous depositions known as Lewy Bodies (LBs). The transition of α-synuclein from its physiological to pathological form has been associated with several post-translational modifications such as phosphorylation and an increasing degree of insolubility, which also correlate with disease progression in post-mortem specimens from human patients. Neuronal expression of α-synuclein in model organisms, including

Indexed as

SynucleinopathiesAgedalpha-SynucleinAnimalsDetergentsDrosophila melanogasterHumansalpha-SynucleinDetergentschemical fractionationDrosophilaParkinson’s diseaseSDSsynucleinopathyα-synuclein

Identifiers

PMID38612454
PMCPMC11011978
OpenAlexW4393142786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.