Evidence map›Paper›PMID 38611926›Full record

ArticleMolecules (Basel, Switzerland)2024

Synthesis of 4'-Thionucleoside Analogues Bearing a C2' Stereogenic All-Carbon Quaternary Center.

Carla Eymard, Amarender Manchoju, Abir Almazloum, Starr Dostie, Michel Prévost, Mona Nemer, Yvan Guindon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carla EymardBioorganic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.ORCID 0000-0002-6551-9861
Amarender ManchojuBioorganic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.ORCID 0000-0001-8601-059X
Abir AlmazloumDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.ORCID 0009-0008-7020-5446
Starr DostieBioorganic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.
Michel PrévostBioorganic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.
Mona NemerDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Yvan GuindonBioorganic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.ORCID 0000-0002-3057-0456

Funding

CIHR 145885
6 · The paper itself

Abstract

The design of novel 4'-thionucleoside analogues bearing a C2' stereogenic all-carbon quaternary center is described. The synthesis involves a highly diastereoselective Mukaiyama aldol reaction, and a diastereoselective radical-based vinyl group transfer to generate the all-carbon stereogenic C2' center, along with different approaches to control the selectivity of the

Indexed as

CarbonCardiac GlycosidesCyclizationGlycosylationThionucleosidesCarbonCardiac GlycosidesThionucleosidesacyclic approachkinetic resolutionquaternary stereocenterSN2-like cyclizationsynthesisthionucleoside analogues

Identifiers

PMID38611926
PMCPMC11013827

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.