Evidence map›Paper›PMID 38611890›Full record

ArticleMolecules (Basel, Switzerland)2024

Antiprotozoal Activity of Plants Used in the Management of Sleeping Sickness in Angola and Bioactivity-Guided Fractionation of

Nina Vahekeni, Théo Brillatz, Marjan Rahmaty, Monica Cal, Sonja Keller-Maerki, Romina Rocchetti, Marcel Kaiser, Sibylle Sax, Kevin Mattli, Evelyn Wolfram and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Nina VahekeniDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.
Théo BrillatzSchool of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva, Switzerland.ORCID 0000-0002-4769-4084
Marjan RahmatySchool of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva, Switzerland.
Monica CalDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.
Sonja Keller-MaerkiDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.
Romina RocchettiDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.
Marcel KaiserDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.ORCID 0000-0003-1785-7302
Sibylle SaxDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.
Kevin MattliPhytopharmacy & Natural Products, Institute of Chemistry and Biotechnology, Zürich University of Applied Sciences (ZHAW), 8820 Wädenswil, Switzerland.
Evelyn WolframPhytopharmacy & Natural Products, Institute of Chemistry and Biotechnology, Zürich University of Applied Sciences (ZHAW), 8820 Wädenswil, Switzerland.
Laurence MarcourtSchool of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva, Switzerland.ORCID 0000-0002-9614-1099
Emerson Ferreira QueirozSchool of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva, Switzerland.ORCID 0000-0001-9567-1664
Jean-Luc WolfenderSchool of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva, Switzerland.ORCID 0000-0002-0125-952X
Pascal MäserDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.ORCID 0000-0003-3122-1941
Swiss Tropical and Public Health Institute · CHUniversity of Geneva · CHZHAW Zurich University of Applied Sciences · CH

Funding

the Swiss National Science Foundation CRSII5_183536
6 · The paper itself

Abstract

Folk medicine is widely used in Angola, even for human African trypanosomiasis (sleeping sickness) in spite of the fact that the reference treatment is available for free. Aiming to validate herbal remedies in use, we selected nine medicinal plants and assessed their antitrypanosomal activity. A total of 122 extracts were prepared using different plant parts and solvents. A total of 15 extracts from seven different plants exhibited in vitro activity (>70% at 20 µg/mL) against

Indexed as

Antiprotozoal AgentsNymphaeaTrypanosomiasis, AfricanAngolaAnimalsHumansPlant ExtractsSeedsAntiprotozoal AgentsPlant ExtractsAfrican medicinal plantAngolaantiprotozoalBrasenia schreberiethnopharmacologyNymphaea lotustrypanosomiasis

Identifiers

PMID38611890
PMCPMC11013945
OpenAlexW4393894801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.