Evidence map›Paper›PMID 38611876›Full record

ArticleMolecules (Basel, Switzerland)2024

Design, Synthesis, and Anti-Leukemic Evaluation of a Series of Dianilinopyrimidines by Regulating the Ras/Raf/MEK/ERK and STAT3/c-Myc Pathways.

Chaoyan Wang, Bo Wang, Yu Mou, Xiang Liu, Qiqing Chen, Weidong Pu, Qing Rao, Chunlin Wang, Jingrui Song, Yubing Huang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Chaoyan WangState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Bo WangState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Yu MouState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Xiang LiuState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Qiqing ChenState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Weidong PuState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Qing RaoState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Chunlin WangState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Jingrui SongState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Yubing HuangState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Longjia YanSchool of Pharmaceutical Sciences, Guizhou University, Guiyang 550000, China.
Lei HuangState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Yanmei LiState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Guiyang Medical University · CNKey Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences · CNGuizhou University · CN

Funding

Guizhou Science and Technology Platform Talents QKHRCPT [2019]5106National Natural Science Foundation of China 82360035, 81960546, 81872772, 82260040, 82160808 and 82060738the Guizhou Medical University Research Grant RN21025 and RN21024the Guizhou Provincial Natural Science Foundation QKHPTRC [2020]5008, QKHZC [2020]4Y203, QKHJC-ZK[2021]YB569, QKHJC-ZK[2022]YB293, QKHJC-ZK[2023]YB240the State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University FAMP202005K
6 · The paper itself

Abstract

Although the long-term survival rate for leukemia has made significant progress over the years with the development of chemotherapeutics, patients still suffer from relapse, leading to an unsatisfactory outcome. To discover the new effective anti-leukemia compounds, we synthesized a series of dianilinopyrimidines and evaluated the anti-leukemia activities of those compounds by using leukemia cell lines (HEL, Jurkat, and K562). The results showed that the dianilinopyrimidine analog

Indexed as

LeukemiaLeukemia, Erythroblastic, AcuteAnimalsDimerizationHumansMiceMitogen-Activated Protein Kinase KinasesPhosphorylationProtein Serine-Threonine KinasesSTAT3 Transcription FactorMitogen-Activated Protein Kinase KinasesProtein Serine-Threonine KinasesSTAT3 protein, humanSTAT3 Transcription FactorapoptosisdianilinopyrimidinesleukemiaRas/Raf/MER/ERKSTAT3/c-Myc

Identifiers

PMID38611876
PMCPMC11013136
OpenAlexW4393866892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.