Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NF-κB/MAPK/JNK Signaling Pathway in Lipopolysaccharide-Treated C57BL/6 Mice.

Oladapo F Fagbohun, Wasitha P D W Thilakarathna, Juan Zhou, Christian Lehmann, Guangling Jiao, H P Vasantha Rupasinghe

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

6.6field-weighted citation impact, top 4% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

Signaling pathways of marine-derived natural products on lung injury: from theFrontiers in pharmacology · 2025
Review
Anti-Inflammatory Effect of Extract fromJournal of microbiology and biotechnology · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Oladapo F FagbohunDepartment Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, Canada.ORCID 0000-0002-1340-6697

Wasitha P D W ThilakarathnaDepartment Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, Canada.ORCID 0000-0002-2835-8819

Juan ZhouDepartments of Anaesthesia, Pain Management and Perioperative Medicine, Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada.ORCID 0000-0002-3040-0238

Christian LehmannDepartments of Anaesthesia, Pain Management and Perioperative Medicine, Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada.ORCID 0000-0001-6419-9168

Guangling JiaoDepartment of Process Engineering and Applied Science, Faculty of Engineering, Dalhousie University, Halifax, NS B3H 4R2, Canada.

H P Vasantha RupasingheDepartment Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, Canada.ORCID 0000-0003-3435-0052

Dalhousie University · CAWilmington College · US

Funding

Mitacs IT25866

6 · The paper itself

Abstract

Acute lung injury (ALI) represents a life-threatening condition with high morbidity and mortality despite modern mechanical ventilators and multiple pharmacological strategies. Therefore, there is a need to develop efficacious interventions with minimal side effects. The anti-inflammatory activities of sea cucumber (

Indexed as

Acute Lung InjuryBlueberry PlantsPlant ExtractsSea CucumbersAnimalsAnti-Inflammatory AgentsCytokinesExtracellular Signal-Regulated MAP KinasesInflammationInterleukin-1betaLipopolysaccharidesMAP Kinase Signaling SystemMiceMice, Inbred C57BLNF-kappa BAnti-Inflammatory Agentsblueberry extractCytokinesExtracellular Signal-Regulated MAP KinasesInterleukin-1betaLipopolysaccharidesNF-kappa BPlant ExtractsALICucumaria frondosacytokineinflammationMAPKNF-κBVaccinium angustifolium

Identifiers

PMID38611791

DOI10.3390/molecules29071511

PMCPMC11013731

OpenAlexW4393278978

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.