Evidence map›Paper›PMID 38611754›Full record

ArticleMolecules (Basel, Switzerland)2024

In Silico and Chromatographic Methods for Analysis of Biotransformation of Prospective Neuroprotective Pyrrole-Based Hydrazone in Isolated Rat Hepatocytes.

Alexandrina Mateeva, Magdalena Kondeva-Burdina, Emilio Mateev, Paraskev Nedialkov, Karolina Lyubomirova, Lily Peikova, Maya Georgieva, Alexander Zlatkov

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexandrina MateevaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.ORCID 0000-0003-1905-7130
Magdalena Kondeva-BurdinaDepartment of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.
Emilio MateevDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.ORCID 0000-0002-5885-7213
Paraskev NedialkovDepartment of Pharmacognosy, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.ORCID 0000-0001-5640-6120
Karolina LyubomirovaDepartment of Occupational Medicine, Faculty of Public Health, Medical University-Sofia, 8 Bjalo More Str., 1527 Sofia, Bulgaria.
Lily PeikovaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.
Maya GeorgievaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.
Alexander ZlatkovDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.ORCID 0000-0002-1695-8454
Medical University of Sofia · BG

Funding

European Union-NextGenerationEU BG-RRP-2.004-0004-C01
6 · The paper itself

Abstract

In the current study, chromatographic and in silico techniques were applied to investigate the biotransformation of ethyl 5-(4-bromophenyl)-1-(2-(2-(2-hydroxybenzylidene) hydrazinyl)-2-oxoethyl)-2-methyl-1

Indexed as

HepatocytesMethanolAnimalsBiotransformationChromatography, LiquidHydrazonesProspective StudiesProtein IsoformsRatsHydrazonesMethanolProtein Isoformsbiotransformationchromatographic methodsin silico approachesmetabolismpyrrole–hydrazonesynthesis

Identifiers

PMID38611754
PMCPMC11013089
OpenAlexW4393202177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.