Evidence map›Paper›PMID 38611684›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Association of Genetic Risk for Age-Related Macular Degeneration with Morphological Features of the Retinal Microvascular Network.

Adam Sendecki, Daniel Ledwoń, Aleksandra Tuszy, Julia Nycz, Anna Wąsowska, Anna Boguszewska-Chachulska, Adam Wylęgała, Andrzej W Mitas, Edward Wylęgała, Sławomir Teper

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Adam SendeckiChair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-752 Katowice, Poland.ORCID 0000-0001-7605-8653
Daniel LedwońFaculty of Biomedical Engineering, Silesian University of Technology, 41-800 Zabrze, Poland.ORCID 0000-0001-7704-2901
Aleksandra TuszyFaculty of Biomedical Engineering, Silesian University of Technology, 41-800 Zabrze, Poland.ORCID 0009-0005-1334-0236
Julia NyczInstitute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, 98693 Ilmenau, Germany.
Anna WąsowskaChair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-752 Katowice, Poland.ORCID 0000-0003-0913-4497
Anna Boguszewska-ChachulskaGenomed S.A., 02-971 Warszawa, Poland.
Adam WylęgałaChair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-752 Katowice, Poland.ORCID 0000-0001-7295-4936
Andrzej W MitasFaculty of Biomedical Engineering, Silesian University of Technology, 41-800 Zabrze, Poland.ORCID 0000-0001-7833-5845
Edward WylęgałaChair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-752 Katowice, Poland.ORCID 0000-0002-6707-5790
Sławomir TeperChair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-752 Katowice, Poland.ORCID 0000-0002-0935-8880
Medical University of Silesia · PLSilesian University of Technology · PLGenomed (Poland) · PLTechnische Universität Ilmenau · DE

Funding

National Centre for Research and Development STRATEGMED1/234261/2/NCBR/2014
6 · The paper itself

Abstract

backgroundAge-related macular degeneration (AMD) is a multifactorial disease encompassing a complex interaction between aging, environmental risk factors, and genetic susceptibility. The study aimed to determine whether there is a relationship between the polygenic risk score (PRS) in patients with AMD and the characteristics of the retinal vascular network visualized by optical coherence tomography angiography (OCTA).

methods235 patients with AMD and 97 healthy controls were included. We used data from a previous AMD PRS study with the same group. The vascular features from different retina layers were compared between the control group and the patients with AMD. The association between features and PRS was then analyzed using univariate and multivariate approaches.

resultsSignificant differences between the control group and AMD patients were found in the vessel diameter distribution (variance:

conclusionsThe vascular features of the retina do not constitute a biomarker of the risk of AMD. We have not identified a genotype-phenotype relationship, and the expression of AMD-related genes is perhaps not associated with the characteristics of the retinal vascular network.

Indexed as

age-related macular degenerationoptical coherence tomography angiographypolygenic risk scoreretinal image analysisretinal vascular network

Identifiers

PMID38611684
PMCPMC11011905
OpenAlexW4393993015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.