Evidence map›Paper›PMID 38611676›Full record

ReviewDiagnostics (Basel, Switzerland)2024

Diagnosing Cystic Fibrosis in the 21st Century-A Complex and Challenging Task.

Dana-Teodora Anton-Păduraru, Alice Nicoleta Azoicăi, Felicia Trofin, Dana Elena Mîndru, Alina Mariela Murgu, Ana Simona Bocec, Codruța Olimpiada Iliescu Halițchi, Carmen Iulia Ciongradi, Ioan Sȃrbu, Maria Liliana Iliescu

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dana-Teodora Anton-PăduraruDepartment of Mother and Child Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaṣi, Romania.ORCID 0000-0001-8657-378X
Alice Nicoleta AzoicăiDepartment of Mother and Child Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaṣi, Romania.
Felicia TrofinDepartment of Preventive Medicine and Interdisciplinarity-Microbiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaṣi, Romania.ORCID 0000-0002-8551-3053
Dana Elena MîndruDepartment of Mother and Child Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaṣi, Romania.
Alina Mariela MurguDepartment of Mother and Child Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaṣi, Romania.
Ana Simona BocecDepartment of Mother and Child Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaṣi, Romania.
Codruța Olimpiada Iliescu HalițchiDepartment of Mother and Child Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaṣi, Romania.ORCID 0000-0003-4762-6476
Carmen Iulia Ciongradi"Sf.Maria" Children Emergency Hospital, 700309 Iasi, Romania.ORCID 0000-0003-0673-0736
Ioan Sȃrbu"Sf.Maria" Children Emergency Hospital, 700309 Iasi, Romania.ORCID 0000-0002-8813-4112
Maria Liliana IliescuDepartment of Preventive Medicine and Interdisciplinarity-Public Health and Health Management, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaṣi, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystic fibrosis (CF) is a chronic and potentially life-threatening condition, wherein timely diagnosis assumes paramount significance for the prompt initiation of therapeutic interventions, thereby ameliorating pulmonary function, addressing nutritional deficits, averting complications, mitigating morbidity, and ultimately enhancing the quality of life and extending longevity. This review aims to amalgamate existing knowledge to provide a comprehensive appraisal of contemporary diagnostic modalities pertinent to CF in the 21st century. Deliberations encompass discrete delineations of each diagnostic modality and the elucidation of potential diagnostic quandaries encountered in select instances, as well as the delineation of genotype-phenotype correlations germane to genetic counseling endeavors. The synthesis underscores that, notwithstanding the availability and strides in diagnostic methodologies, including genetic assays, the sweat test (ST) retains its position as the preeminent diagnostic standard for CF, serving as a robust surrogate for CFTR functionality. Prospective clinical investigations in the realm of CF should be orchestrated with the objective of discerning novel diagnostic modalities endowed with heightened specificity and sensitivity.

Indexed as

childrencystic fibrosisdiagnosticgeneticneonatal screeningsweat test

Identifiers

PMID38611676
PMCPMC11012009

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.