Evidence map›Paper›PMID 38611604›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Multiparametric Cardiac Magnetic Resonance Assessment in Sickle Beta Thalassemia.

Laura Pistoia, Antonella Meloni, Vincenzo Positano, Filomena Longo, Zelia Borsellino, Anna Spasiano, Riccardo Righi, Stefania Renne, Daniela Izzo, Ketty Savino and 4 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Laura PistoiaUnità Operativa Complessa Ricerca Clinica, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy.ORCID 0000-0002-5319-2769
Antonella MeloniDepartment of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy.ORCID 0000-0002-2284-8585
Vincenzo PositanoDepartment of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy.ORCID 0000-0001-6955-9572
Filomena LongoUnità Operativa Day Hospital della Talassemia e delle Emoglobinopatie, Azienda Ospedaliero-Universitaria "S. Anna", 44124 Ferrara, Italy.ORCID 0000-0002-0434-0382
Zelia BorsellinoUnità Operativa Complessa Ematologia con Talassemia, ARNAS Civico "Benfratelli-Di Cristina", 90134 Palermo, Italy.
Anna SpasianoUnità Operativa Semplice Dipartimentale Malattie Rare del Globulo Rosso, Azienda Ospedaliera di Rilievo Nazionale "A. Cardarelli", 80131 Napoli, Italy.
Riccardo RighiDiagnostica per Immagini e Radiologia Interventistica, Ospedale del Delta, 44023 Ferrara, Italy.
Stefania RenneStruttura Complessa di Cardioradiologia-UTIC, Presidio Ospedaliero "Giovanni Paolo II", 88046 Cosenza, Italy.
Daniela IzzoUnità Operativa Complessa di Cardiologia-UTIC, Presidio Ospedaliero "D.ssa Anastasia Guerriero", 81025 Caserta, Italy.ORCID 0000-0001-9960-9489
Ketty SavinoSezione di Cardiologia e Fisiopatologia Cardiovascolare, Dipartimento di Medicina e Chirurgia, Università degli Studi di Perugia, 06132 Perugia, Italy.
Sophie MavrogeniOnassis Cardiac Surgery Center, 17674 Athens, Greece.
Emilio QuaiaIstituto di Radiologia, Dipartimento di Medicina, Università di Padova, 35128 Padova, Italy.ORCID 0000-0003-2020-9365
Filippo CademartiriDepartment of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy.ORCID 0000-0002-0579-3279
Alessia PepeIstituto di Radiologia, Dipartimento di Medicina, Università di Padova, 35128 Padova, Italy.ORCID 0000-0001-6401-3829
Fondazione Toscana Gabriele Monasterio · ITPresidio Ospedaliero · ITUniversity of Padua · ITArcispedale Sant'Anna · ITAzienda di Rilievo Nazionale ed Alta Specializzazione · ITAzienda Unità Sanitaria Locale di Ferrara · ITOnassis Cardiac Surgery Center · GRUniversity of Perugia · IT

Funding

The MIOT project received "no-profit support" from Chiesi Farmaceutici S.p.A. and ApoPharma Inc.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NA
6 · The paper itself

Abstract

Cardiac involvement in sickle beta thalassemia (Sβ-thal) patients has been poorly investigated. We aimed to evaluate cardiac function and myocardial iron overload by cardiovascular magnetic resonance (CMR) in patients with Sβ-thal. One-hundred and eleven Sβ-thal patients consecutively enrolled in the Myocardial Iron Overload in Thalassemia (MIOT) network were studied and compared with 46 sickle cell anemia (SCA) patients and with 111 gender- and age- matched healthy volunteers. Cine images were acquired to quantify biventricular function. Myocardial iron overload (MIO) was assessed by the T2* technique, while macroscopic myocardial fibrosis was evaluated by the late gadolinium enhancement (LGE) technique. In Sβ-thal and SCA patients, the morphological and functional CMR parameters were not significantly different, except for the left atrial area and left ventricular (LV) stroke volume, indexed by body surface area (

Indexed as

iron overloadmagnetic resonance imagingsickle beta-thalassemia

Identifiers

PMID38611604
PMCPMC11012026
OpenAlexW4393187474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.