Evidence map›Paper›PMID 38611036›Full record

ArticleCancers2024

Utility Scores for Risk-Reducing Mastectomy and Risk-Reducing Salpingo-Oophorectomy: Mapping to EQ-5D.

Samuel G Oxley, Xia Wei, Michail Sideris, Oleg Blyuss, Ashwin Kalra, Jacqueline J Y Sia, Subhasheenee Ganesan, Caitlin T Fierheller, Li Sun, Zia Sadique and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Samuel G OxleyWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0003-1967-813X
Xia WeiWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0001-5005-059X
Michail SiderisWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0002-4199-6700
Oleg BlyussWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.
Ashwin KalraWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.
Jacqueline J Y SiaWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.
Subhasheenee GanesanWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.
Caitlin T FierhellerWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0001-9583-3061
Li SunDepartment of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London WC1H 9SH, UK.ORCID 0000-0001-5569-7296
Zia SadiqueDepartment of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London WC1H 9SH, UK.ORCID 0000-0001-5814-0258
Haomiao JinSchool of Health Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7YH, UK.ORCID 0000-0001-8908-1959
Ranjit ManchandaWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0003-3381-5057
Rosa LegoodWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0003-2761-5227

Funding

Barts Charity G-001522Rosetrees Trust CF1\100001
6 · The paper itself

Abstract

backgroundRisk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) are the most effective breast and ovarian cancer preventive interventions. EQ-5D is the recommended tool to assess the quality of life and determine health-related utility scores (HRUSs), yet there are no published EQ-5D HRUSs after these procedures. These are essential for clinicians counselling patients and for health-economic evaluations.

methodsWe used aggregate data from our published systematic review and converted SF-36/SF-12 summary scores to EQ-5D HRUSs using a published mapping algorithm. Study control arm or age-matched country-specific reference values provided comparison. Random-effects meta-analysis provided adjusted disutilities and utility scores. Subgroup analyses included long-term vs. short-term follow-up.

resultsFour studies (209 patients) reported RRM outcomes using SF-36, and five studies (742 patients) reported RRSO outcomes using SF-12/SF-36. RRM is associated with a long-term (>2 years) disutility of -0.08 (95% CI -0.11, -0.04) (I

conclusionsWe present the first HRUSs sourced from patients following RRM and RRSO. There is a need for high-quality prospective studies to characterise quality of life at different timepoints.

Indexed as

mappingrisk-reducing mastectomyrisk-reducing salpingo-oophorectomyutility scores

Identifiers

PMID38611036
PMCPMC11010846

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.