Evidence map›Paper›PMID 38610988›Full record

ReviewCancers2024

Autoimmune Atrophic Gastritis: A Clinical Review.

Chiara Castellana, Leonardo Henry Eusebi, Elton Dajti, Veronica Iascone, Amanda Vestito, Pietro Fusaroli, Lorenzo Fuccio, Antonietta D'Errico, Rocco Maurizio Zagari

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
33.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Gastric Carcinoma: Diagnosis, Staging, and Treatment.Deutsches Arzteblatt international · 2026
    Guideline
  4. Pooled it
  5. Journal of translational autoimmunity · 2026
    Article
  6. Review
  7. The long-lived immune system of centenarians.Nature reviews. Immunology · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Immunological mechanisms of autoimmune gastritis.Clinical and experimental medicine · 2026
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chiara CastellanaDepartment of Medical Sciences and Surgery, University of Bologna, 40138 Bologna, Italy.
Leonardo Henry EusebiDepartment of Medical Sciences and Surgery, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-3323-7744
Elton DajtiDepartment of Medical Sciences and Surgery, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-2905-1146
Veronica IasconeDepartment of Medical Sciences and Surgery, University of Bologna, 40138 Bologna, Italy.
Amanda VestitoGastroenterology Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Pietro FusaroliDepartment of Medical Sciences and Surgery, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-4397-9314
Lorenzo FuccioDepartment of Medical Sciences and Surgery, University of Bologna, 40138 Bologna, Italy.
Antonietta D'ErricoDepartment of Medical Sciences and Surgery, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-2747-3732
Rocco Maurizio ZagariDepartment of Medical Sciences and Surgery, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0001-9949-8619
Azienda USL di Bologna · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune atrophic gastritis (AAG) is a chronic condition characterized by the presence of atrophy in the oxyntic mucosa due to anti-parietal cell antibodies. This review provides a comprehensive and up-to-date overview of autoimmune atrophic gastritis, reporting recent evidence on epidemiology, pathogenesis, diagnosis, clinical presentation, risk of malignancies, and management. The prevalence of AAG has been estimated at between 0.3% and 2.7% in the general population. The diagnosis of AAG is based on a combination of the serologic profile and the histological examination of gastric biopsies. Patients with AAG are often asymptomatic but can also have dyspeptic or reflux symptoms. The atrophy of the oxyntic mucosa leads to iron and vitamin B12 malabsorption, which may result in anemia and neurological affections. Autoimmune atrophic gastritis is associated with an increased risk of type I neuroendocrine tumors (NETs) and gastric cancer, with an incidence rate of 2.8% and 0.5% per person/year, respectively. Management is directed to reinstate vitamins and iron and to prevent malignancies with endoscopic surveillance. In conclusion, atrophic autoimmune gastritis is an infrequent condition, often asymptomatic and misdiagnosed, that requires an early diagnosis for appropriate vitamin supplementation and endoscopic follow-up for the early diagnosis of NETs and gastric cancer.

Indexed as

anti-parietal cell antibodiesautoimmune atrophic gastritisgastric carcinoids

Identifiers

PMID38610988
PMCPMC11010983
OpenAlexW4393254586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.