ReviewJournal of clinical medicine2024
Anemia and Its Connections to Inflammation in Older Adults: A Review.
Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Risk factors of inflammatory bowel disease complicating anemia: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Association between cumulative biological risk and hypertension in older adults in Korea: a population-based cross-sectional study.Journal of Korean biological nursing science · 2026Article
- An Almond Meal-Rich Diet Improves Red Blood Cell Count and Reduces Odds of Anemia in a Mouse Model of Aging.Antioxidants (Basel, Switzerland) · 2026Article
- A sustained-release depot formulation of β-nicotinamide mononucleotide for alleviating chemotherapy-induced myelosuppression.Materials today. Bio · 2026Article
- Anemia as an independent risk factor for sarcopenia in older adults: a cohort study based on CHARLS and ELSA.Scientific reports · 2026Article
- Treatment of Hypovitaminosis D Is Associated with Improvement in Anemia of Inflammation in Patients with Decompensated Cirrhosis.Medical sciences (Basel, Switzerland) · 2026Article
- Relationship Between Anemia and Oral Lichen Planus: New Therapeutic Perspectives Based on Anemia Management-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Identification of Symptom Clusters and Core Symptoms in Inflammatory Bowel Disease: A Network Analysis in Chinese Cohorts.Gastroenterology research and practice · 2026Article
- The synergy of nutritional risk and iron deficiency as a predictor of mortality in older emergency department patients.Frontiers in medicine · 2026Article
- Impact of Anemia on Outcomes Following Total Hip Replacement Surgery and Patient Prognosis.Orthopaedic surgery · 2026Review
- Anaemia, Iron Deficiency, and Functional Outcomes in Rural Older Indians: Insights from the Odisha Tribal Family Health Survey.The journal of nutrition, health & aging · 2026Article
- Analysis of Long COVID characteristics and risk factors in individuals infected with COVID-19: a follow-up study based on a cohort of 2,792 participants.Frontiers in public health · 2026Article
- Identification of reproductive and molecular biomarkers associated with clinical metritis in dromedary camels (Frontiers in veterinary science · 2026Article
- Chronic obstructive pulmonary disease (COPD) and autoimmune diseases: unravelling complex interactions.Annals of medicine · 2025Review
- Frailty and Anemia in Geriatric Care: A Retrospective Cohort Study.The American journal of nursing · 2025Article
- Development and validation of a predictive nomogram for sepsis-associated severe anemia.The Journal of international medical research · 2025Article
- Article
- Association between the systemic immune-inflammation index and anemia among US children: national health and nutrition examination survey (NHANES), 2001-2018.BMC pediatrics · 2025Article
- The hidden burden of anemia in elderly surgical patients: a prospective study on incidence and contributing factors.BMC geriatrics · 2025Observational
- Non-Anemic Iron Deficiency Predicts COPD Exacerbations and Hospitalizations: Results from a Prospective Cohort.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anemia is a common hematological disorder that affects 12% of the community-dwelling population, 40% of hospitalized patients, and 47% of nursing home residents. Our understanding of the impact of inflammation on iron metabolism and erythropoiesis is still lacking. In older adults, anemia can be divided into nutritional deficiency anemia, bleeding anemia, and unexplained anemia. The last type of anemia might be caused by reduced erythropoietin (EPO) activity, progressive EPO resistance of bone marrow erythroid progenitors, and the chronic subclinical pro-inflammatory state. Overall, one-third of older patients with anemia demonstrate a nutritional deficiency, one-third have a chronic subclinical pro-inflammatory state and chronic kidney disease, and one-third suffer from anemia of unknown etiology. Understanding anemia's pathophysiology in people aged 65 and over is crucial because it contributes to frailty, falls, cognitive decline, decreased functional ability, and higher mortality risk. Inflammation produces adverse effects on the cells of the hematological system. These effects include iron deficiency (hypoferremia), reduced EPO production, and the elevated phagocytosis of erythrocytes by hepatic and splenic macrophages. Additionally, inflammation causes enhanced eryptosis due to oxidative stress in the circulation. Identifying mechanisms behind age-related inflammation is essential for a better understanding and preventing anemia in older adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.