Evidence map›Paper›PMID 38610406›Full record

ArticleSensors (Basel, Switzerland)2024

Sensor-Based Quantification of MDS-UPDRS III Subitems in Parkinson's Disease Using Machine Learning.

Rene Peter Bremm, Lukas Pavelka, Maria Moscardo Garcia, Laurent Mombaerts, Rejko Krüger, Frank Hertel, NCER-PD Consortium

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rene Peter BremmNational Department of Neurosurgery, Centre Hospitalier de Luxembourg, 1210 Luxembourg, Luxembourg.ORCID 0000-0002-6782-4026
Lukas PavelkaParkinson's Research Clinic, Centre Hospitalier de Luxembourg, 1210 Luxembourg, Luxembourg.
Maria Moscardo GarciaSystems Control, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg.
Laurent MombaertsNational Department of Neurosurgery, Centre Hospitalier de Luxembourg, 1210 Luxembourg, Luxembourg.
Rejko KrügerParkinson's Research Clinic, Centre Hospitalier de Luxembourg, 1210 Luxembourg, Luxembourg.
Frank HertelNational Department of Neurosurgery, Centre Hospitalier de Luxembourg, 1210 Luxembourg, Luxembourg.
NCER-PD Consortium
Centre Hospitalier de Luxembourg · LUUniversity of Luxembourg · LU

Funding

Wellcome Trust
6 · The paper itself

Abstract

Wearable sensors could be beneficial for the continuous quantification of upper limb motor symptoms in people with Parkinson's disease (PD). This work evaluates the use of two inertial measurement units combined with supervised machine learning models to classify and predict a subset of MDS-UPDRS III subitems in PD. We attached the two compact wearable sensors on the dorsal part of each hand of 33 people with PD and 12 controls. Each participant performed six clinical movement tasks in parallel with an assessment of the MDS-UPDRS III. Random forest (RF) models were trained on the sensor data and motor scores. An overall accuracy of 94% was achieved in classifying the movement tasks. When employed for classifying the motor scores, the averaged area under the receiver operating characteristic values ranged from 68% to 92%. Motor scores were additionally predicted using an RF regression model. In a comparative analysis, trained support vector machine models outperformed the RF models for specific tasks. Furthermore, our results surpass the literature in certain cases. The methods developed in this work serve as a base for future studies, where home-based assessments of pharmacological effects on motor function could complement regular clinical assessments.

Indexed as

Parkinson DiseaseHandHumansMachine LearningMovementSupervised Machine Learninginertial measurement unitmachine learningMDS-UPDRSmotor symptomsParkinson’s diseaserandom forestwearable devices

Identifiers

PMID38610406
PMCPMC11014392
OpenAlexW4393309798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.