Evidence map›Paper›PMID 38610085›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2024

A special role for anterior cingulate cortex, but not orbitofrontal cortex or basolateral amygdala, in choices involving information.

Valeria V González, Yifan Zhang, Sonya A Ashikyan, Anne Rickard, Ibrahim Yassine, Juan Luis Romero-Sosa, Aaron P Blaisdell, Alicia Izquierdo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Valeria V GonzálezDepartment of Psychology, University of California-Los Angeles, 502 Portola Plaza, Los Angeles, CA 90095, United States.
Yifan ZhangDepartment of Computer Science, University of Southern California, Salvatori Computer Science Center, 941 Bloom Walk, Los Angeles, CA 90089, United States.
Sonya A AshikyanDepartment of Psychology, University of California-Los Angeles, 502 Portola Plaza, Los Angeles, CA 90095, United States.
Anne RickardDepartment of Psychology, University of California-Los Angeles, 502 Portola Plaza, Los Angeles, CA 90095, United States.
Ibrahim YassineDepartment of Psychology, University of California-Los Angeles, 502 Portola Plaza, Los Angeles, CA 90095, United States.
Juan Luis Romero-SosaDepartment of Psychology, University of California-Los Angeles, 502 Portola Plaza, Los Angeles, CA 90095, United States.
Aaron P BlaisdellDepartment of Psychology, University of California-Los Angeles, 502 Portola Plaza, Los Angeles, CA 90095, United States.
Alicia IzquierdoDepartment of Psychology, University of California-Los Angeles, 502 Portola Plaza, Los Angeles, CA 90095, United States.
University of California, Los Angeles · USUniversity of Southern California · US

Funding

CRCNS Research Proposal: Cortico-amygdalar substrates of adaptive learningR01DA047870 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alicia Izquierdo, Alireza Soltani · 2018 to 2026
$4.1M
NIDA NIH HHS R01 DA047870
6 · The paper itself

Abstract

Subjects are often willing to pay a cost for information. In a procedure that promotes paradoxical choices, animals choose between a richer option followed by a cue that is rewarded 50% of the time (No Info) vs. a leaner option followed by one of two cues that signal certain outcomes: one always rewarded (100%) and the other never rewarded, 0% (Info). Since decisions involve comparing the subjective value of options after integrating all their features, preference for information may rely on cortico-amygdalar circuitry. To test this, male and female rats were prepared with bilateral inhibitory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) in the anterior cingulate cortex, orbitofrontal cortex, basolateral amygdala, or null virus (control). We inhibited these regions after stable preference was acquired. We found that inhibition of the anterior cingulate cortex destabilized choice preference in female rats without affecting latency to choose or response rate to cues. A logistic regression fit revealed that previous choice predicted current choice in all conditions, however previously rewarded Info trials strongly predicted preference in all conditions except in female rats following anterior cingulate cortex inhibition. The results reveal a causal, sex-dependent role for the anterior cingulate cortex in decisions involving information.

Indexed as

Basolateral Nuclear ComplexAmygdalaAnimalsCuesFemaleGyrus CinguliHumansMalePrefrontal CortexRatschemogeneticsfrontal cortexinformation-seekingvalue-based decision making

Identifiers

PMID38610085
PMCPMC11014886
OpenAlexW4394765404

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.