Evidence map›Paper›PMID 38609547›Full record

ArticleNature immunology2024

Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis.

Marisol Alvarez-Martinez, Luke S Cox, Claire F Pearson, William J Branchett, Probir Chakravarty, Xuemei Wu, Hubert Slawinski, Alaa Al-Dibouni, Vasileios A Samelis, Leona Gabryšová and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Marisol Alvarez-Martinez *Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK.
Luke S Cox *Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-5477-8622
Claire F PearsonKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5816-1657
William J BranchettImmunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK.
Probir ChakravartyComputational Biology Laboratory, The Francis Crick Institute, London, UK.
Xuemei WuImmunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK.
Hubert SlawinskiAdvanced Sequencing Facility, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-8996-8477
Alaa Al-DibouniImmunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK.
Vasileios A SamelisImmunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-8986-7385
Leona GabryšováImmunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK.
Simon L PriestnallDepartment of Pathobiology and Population Sciences, Royal Veterinary College, London, UK.ORCID http://orcid.org/0000-0002-6027-1879
Alejandro Suárez-BonnetDepartment of Pathobiology and Population Sciences, Royal Veterinary College, London, UK.
Anna MikolajczakExperimental Histopathology, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0009-0002-0603-6867
James BriscoeDevelopmental Dynamics Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-1020-5240
Fiona PowrieKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-3312-5929
Anne O'GarraImmunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK. Anne.OGarra@crick.ac.uk.ORCID http://orcid.org/0000-0001-9845-6134
The Francis Crick Institute · GBRoyal Veterinary College · GBUniversity of Oxford · GBImperial College London · GB

Funding

Wellcome Trust FC001126
6 · The paper itself

Abstract

Intestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified CD4

Indexed as

ColitisHelicobacter hepaticusMice, KnockoutPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-mafAnimalsDisease Models, AnimalGene Expression RegulationHelicobacter InfectionsHumansInflammatory Bowel DiseasesIntestinal MucosaMiceMice, Inbred C57BLMaf protein, mousePositive Regulatory Domain I-Binding Factor 1Prdm1 protein, mouseProto-Oncogene Proteins c-maf

Identifiers

PMID38609547
PMCPMC11065689
OpenAlexW4394764796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.